Document Detail

Lowering dietary protein to U.S. Recommended dietary allowance levels reduces urinary calcium excretion and bone resorption in young women.
MedLine Citation:
PMID:  15292308     Owner:  NLM     Status:  MEDLINE    
High-protein diets increase calciuria. No previous studies have examined the ad libitum U.S. diet's effect on calciuria or bone resorption.Thirty-nine healthy, premenopausal women consuming ad libitum diets [mean, 1.1 g/kg protein, 819 mg (20.5 mmol) Ca, 1152 mg (37 mmol) P, 129 mmol Na] were switched to isocaloric diets containing the U.S. recommended dietary allowance (RDA) of protein (0.8 g/kg) and similar amounts of calcium, phosphorus, and sodium. Bone resorption and related endpoints were assessed before and 1 wk after the switch. As dietary protein changed from ad libitum to RDA levels, mean urine nitrogen decreased 26% (2.4 g/d; P < 0.001) and mean blood urea nitrogen decreased 15% (1.9 mg/dl; P < 0.001). Mean urine pH increased from 6.3 to 6.8 (P < 0.001), and net renal acid excretion (NRAE = urine ammonium plus titratable acids minus bicarbonate) decreased 68% (21.4 mEq/d; P < 0.001). Mean urinary calcium decreased 32% [42 mg (1 mmol)/d; P < 0.001], and bone resorption urine N-telopeptides) decreased 17% (74 micromol bovine collagen equivalents/d; P < 0.001). Mean serum calcium, PTH, and 1,25 dihydroxy vitamin D remained unchanged. In this 2-wk study, decreasing dietary protein from ad libitum to RDA levels decreased NRAE, calciuria and estimates of bone resorption, suggesting that decreased U.S. protein consumption might reduce bone loss. Inasmuch as other dietary modifications, such as increasing vegetable and fruit intake, can result in sustained reductions in NRAE without reducing protein intake, the advisability of reducing protein intake for skeletal protection from acid attack requires further investigation.
B Avery Ince; Ellen J Anderson; Robert M Neer
Related Documents :
1019078 - Calcium balance in the quail (coturnix coturnix japonica). 1, influence of sex and diet...
22024078 - Upregulation of nrf2 expression in non-alcoholic fatty liver and steatohepatitis.
3392608 - The effect of high calcium and/or high protein diet on bone growth in growing rats kept...
16223518 - Effects of 1,25-dihydroxicolecalciferol and dietary calcium-phosphate on distribution o...
16227788 - Glucose metabolism, lipid, and body fat changes in antiretroviral-naive subjects random...
11160558 - Atherogenic lipoprotein phenotype and diet-gene interactions.
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of clinical endocrinology and metabolism     Volume:  89     ISSN:  0021-972X     ISO Abbreviation:  J. Clin. Endocrinol. Metab.     Publication Date:  2004 Aug 
Date Detail:
Created Date:  2004-08-04     Completed Date:  2004-09-03     Revised Date:  2009-11-03    
Medline Journal Info:
Nlm Unique ID:  0375362     Medline TA:  J Clin Endocrinol Metab     Country:  United States    
Other Details:
Languages:  eng     Pagination:  3801-7     Citation Subset:  AIM; IM    
Endocrine Division, Massachusetts General Hospital, Boston, Massachusetts 02114 , USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Acids / urine
Blood Urea Nitrogen
Bone Resorption / prevention & control*
Calcium / urine*
Collagen / urine
Collagen Type I
Dietary Proteins / administration & dosage*
Dose-Response Relationship, Drug
Hydrogen-Ion Concentration
Nitrogen / urine
Nutrition Policy*
Peptides / urine
Urine / chemistry
Grant Support
M01 RR01066/RR/NCRR NIH HHS; U01-A612531//PHS HHS
Reg. No./Substance:
0/Acids; 0/Collagen Type I; 0/Dietary Proteins; 0/Peptides; 0/collagen type I trimeric cross-linked peptide; 7440-70-2/Calcium; 7727-37-9/Nitrogen; 9007-34-5/Collagen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Jugular venous sampling: an alternative to petrosal sinus sampling for the diagnostic evaluation of ...
Next Document:  Impact of ovarian hyperstimulation on thyroid function in women with and without thyroid autoimmunit...