| Lowering of blood pressure leads to decreased circulating interleukin-6 in hypertensive subjects. | |
| | |
MedLine Citation:
|
PMID: 15759024 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Interleukin-6 (IL-6), the major proinflammatory cytokine, has been described to be associated with the hypertensive and atherosclerotic states. We aimed to explore whether the concentration of circulating IL-6 and adhesion molecules could be modified by decreasing blood pressure in hypertensive subjects. A total of 30 subjects (18 men), aged 34-48 years, were enrolled in this study, 17 hypertensive never-treated patients (HTA) and 13 normotensive subjects (C). HTA subjects were treated with irbesartan, 150-300 mg/day for 3 months, and serum IL-6, vascular cell adhesion molecule-1, intercellular adhesion molecule-1, sP-selectin, sE-selectin and monocyte chemoattractant protein-1 were measured at 0 and 12 weeks. The two study groups were similar in age, body mass index (BMI) and gender. At baseline, circulating IL-6 levels, but not adhesion molecules, were significantly associated with systolic blood pressure (r=0.41; P=0.03) and BMI (r=0.53; P=0.005). Systolic and diastolic blood pressure decreased significantly (P<0.01) in parallel to serum IL-6 levels (from 3.72+/-0.82 to 3.23+/-0.19 pg/ml, P=0.02) reaching a similar concentration to normotensive patients (3.33+/-0.3 pg/ml) after treatment with irbesartan. No significant changes were observed in any other of the tested parameters. In conclusion, the treatment of high blood pressure lowers circulating IL-6 in young hypertensive patients. |
| | |
Authors:
|
G Vázquez-Oliva; J M Fernández-Real; A Zamora; M Vilaseca; L Badimón |
Related Documents
:
|
10775564 - Cellular hypertrophy in subcutaneous small arteries of patients with renovascular hyper... 4053514 - Kinetics of bumetanide-sensitive na+-k+ co-transport in erythrocytes of essential hyper... 758494 - Family (parental) history and prevalence of hypertension. results of a nationwide scree... 1848264 - Hyperkinetic borderline hypertension in tecumseh, michigan. 21445934 - The co-occurrence of obesity, elevated blood pressure, and acanthosis nigricans among a... 10565524 - Is neuroprotection a viable therapy for glaucoma? |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Journal of human hypertension Volume: 19 ISSN: 0950-9240 ISO Abbreviation: J Hum Hypertens Publication Date: 2005 Jun |
Date Detail:
|
Created Date: 2005-05-19 Completed Date: 2005-08-23 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 8811625 Medline TA: J Hum Hypertens Country: England |
Other Details:
|
Languages: eng Pagination: 457-62 Citation Subset: IM |
Affiliation:
|
Cardiology Unit, Hospital de Blanes, Corporació de Salut del Maresme i La Selva, Girona, Spain. gvazquez@salutms.org |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Antihypertensive Agents / therapeutic use* Biphenyl Compounds / therapeutic use* Blood Pressure / drug effects* Case-Control Studies Cell Adhesion Molecules / blood Diastole Female Humans Hypertension / blood*, drug therapy* Interleukin-6 / antagonists & inhibitors, blood* Male Middle Aged Systole Tetrazoles / therapeutic use* |
| Chemical | |
Reg. No./Substance:
|
0/Antihypertensive Agents; 0/Biphenyl Compounds; 0/Cell Adhesion Molecules; 0/Interleukin-6; 0/Tetrazoles; 138402-11-6/irbesartan |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: The effect of treatment on health-related quality of life in patients with hypertension and renal ar...
Next Document: High-dose monotherapy vs low-dose combination therapy of calcium channel blockers and angiotensin re...