| Lowering of Blood Pressure by Chronic Suppression of Central Sympathetic Outflow: Insight from Prolonged Baroreflex Activation. | |
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MedLine Citation:
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PMID: 22797307 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Device-based therapy for resistant hypertension by electrical activation of the carotid baroreflex is currently undergoing active clinical investigation, and initial findings from clinical trials have been published. The purpose of this mini-review is to summarize the experimental studies that have provided a conceptual understanding of the mechanisms that account for the long-term lowering of arterial pressure with baroreflex activation. Because of the well established role of the baroreflex in short-term regulation of arterial pressure by rapidly changing peripheral resistance and cardiac function, the more sluggish actions of the baroreflex on renal excretory function are often not taken into consideration in long-term pressure control. However, since clinical, experimental, and theoretical evidence indicates that the kidneys play a dominant role in long-term control of arterial pressure, this review focuses on the mechanisms that link baroreflex-mediated reductions in central sympathetic outflow with increases in renal excretory function that lead to sustained reductions in arterial pressure. |
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Authors:
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Thomas E Lohmeier; Radu Iliescu |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-7-12 |
Journal Detail:
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Title: Journal of applied physiology (Bethesda, Md. : 1985) Volume: - ISSN: 1522-1601 ISO Abbreviation: - Publication Date: 2012 Jul |
Date Detail:
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Created Date: 2012-7-16 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8502536 Medline TA: J Appl Physiol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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1University of Mississippi Medical Center. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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