Document Detail

Lowering of blood pressure by chronic suppression of central sympathetic outflow: insight from prolonged baroreflex activation.
MedLine Citation:
PMID:  22797307     Owner:  NLM     Status:  MEDLINE    
Device-based therapy for resistant hypertension by electrical activation of the carotid baroreflex is currently undergoing active clinical investigation, and initial findings from clinical trials have been published. The purpose of this mini-review is to summarize the experimental studies that have provided a conceptual understanding of the mechanisms that account for the long-term lowering of arterial pressure with baroreflex activation. The well established mechanisms mediating the role of the baroreflex in short-term regulation of arterial pressure by rapid changes in peripheral resistance and cardiac function are often extended to long-term pressure control, and the more sluggish actions of the baroreflex on renal excretory function are often not taken into consideration. However, because clinical, experimental, and theoretical evidence indicates that the kidneys play a dominant role in long-term control of arterial pressure, this review focuses on the mechanisms that link baroreflex-mediated reductions in central sympathetic outflow with increases in renal excretory function that lead to sustained reductions in arterial pressure.
Thomas E Lohmeier; Radu Iliescu
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review     Date:  2012-07-12
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  113     ISSN:  1522-1601     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-16     Completed Date:  2013-04-29     Revised Date:  2013-12-05    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1652-8     Citation Subset:  IM    
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MeSH Terms
Antihypertensive Agents / therapeutic use
Arterial Pressure* / drug effects
Carotid Sinus / innervation*
Central Nervous System / physiopathology*
Drug Resistance
Electric Stimulation Therapy*
Hypertension / etiology,  metabolism,  physiopathology,  therapy*
Kidney / innervation*
Obesity / complications
Renin-Angiotensin System
Sympathetic Nervous System / physiopathology*
Treatment Outcome
Vascular Resistance
Grant Support
Reg. No./Substance:
0/Antihypertensive Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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