| Lowered microvascular vessel wall oxygen consumption augments tissue pO2 during PgE1-induced vasodilation. | |
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MedLine Citation:
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PMID: 17165051 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Continuous infusion of intravenous prostaglandin E1 (PgE1, 2.5 mug/kg/min) was used to determine how vasodilation affects oxygen consumption of the microvascular wall and tissue pO(2) in the hamster window chamber model. While systemic measurements (mean arterial pressure and heart rate) and central blood gas measurements were not affected, PgE1 treatment caused arteriolar (64.6 +/- 25.1 microm) and venular diameter (71.9 +/- 29.5 microm) to rise to 1.15 +/- 0.21 and 1.06 +/- 0.19, respectively, relative to baseline. Arteriolar (3.2 x 10(-2) +/- 4.3 x 10(-2) nl/s) and venular flow (7.8 x 10(-3) +/- 1.1 x 10(-2)/s) increased to 1.65 +/- 0.93 and 1.32 +/- 0.72 relative to baseline. Interstitial tissue pO(2) was increased significantly from baseline (21 +/- 8 to 28 +/- 7 mmHg; P < 0.001). The arteriolar vessel wall gradient, a measure of oxygen consumption by the microvascular wall decreased from 20 +/- 6 to 16 +/- 3 mmHg (P < 0.001). The arteriolar vessel wall gradient, a measure of oxygen consumption by the vascular wall, decreased from 20 +/- 6 to 16 +/- 3 mmHg (P < 0.001). This reduction reflects a 20% decrease in oxygen consumption by the vessel wall and up to 50% when cylindrical geometry is considered. The venular vessel wall gradient decreased from 12 +/- 4 to 9 +/- 4 mmHg (P < 0.001). Thus PgE1-mediated vasodilation has a positive microvascular effect: enhancement of tissue perfusion by increasing flow and then augmentation of tissue oxygenation by reducing oxygen consumption by the microvascular wall. |
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Authors:
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Barbara Friesenecker; A G Tsai; M W Dünser; J Martini; W Hasibeder; M Intaglietta |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2006-12-13 |
Journal Detail:
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Title: European journal of applied physiology Volume: 99 ISSN: 1439-6319 ISO Abbreviation: Eur. J. Appl. Physiol. Publication Date: 2007 Mar |
Date Detail:
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Created Date: 2007-02-02 Completed Date: 2007-04-24 Revised Date: 2007-12-03 |
Medline Journal Info:
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Nlm Unique ID: 100954790 Medline TA: Eur J Appl Physiol Country: Germany |
Other Details:
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Languages: eng Pagination: 405-14 Citation Subset: IM |
Affiliation:
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Division of General and Surgical Intensive Care Medicine, Department of Anesthesia and Critical Care Medicine, The Leopold-Franzens-University of Innsbruck, Anichstr 35, Innsbruck, Austria. barbara.friesenecker@uibk.ac.at |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Alprostadil
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administration & dosage* Animals Cricetinae Injections, Intravenous Mesocricetus Microcirculation / drug effects, physiology* Oxygen / metabolism* Oxygen Consumption / drug effects, physiology* Vasodilation / drug effects, physiology* Vasodilator Agents / administration & dosage |
| Grant Support | |
ID/Acronym/Agency:
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R01 HL62318/HL/NHLBI NIH HHS; R01 HL62354/HL/NHLBI NIH HHS; R01 HL76182/HL/NHLBI NIH HHS; R24 HL64395/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Vasodilator Agents; 745-65-3/Alprostadil; 7782-44-7/Oxygen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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