Document Detail

Lower whole blood glutathione peroxidase (GPX) activity in depression, but not in myalgic encephalomyelitis / chronic fatigue syndrome: another pathway that may be associated with coronary artery disease and neuroprogression in depression.
MedLine Citation:
PMID:  21552194     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Major depression and myalgic encephalomyelitis / chronic fatigue syndrome (ME/CFS) are two disorders accompanied by an upregulation of the inflammatory and oxidative and nitrosative (IO&NS) pathways and a decreased antioxidant status. Moreover, depression is accompanied by disorders in inflammatory and neuroprogressive (IN-PRO) pathways.
METHODS: This study examines whole blood glutathione peroxidase (GPX) in depression and in ME/CFS; GPX is an enzyme that reduces hydroperoxides by oxidizing glutathione and consequently protects the cells from oxidative damage. Blood was sampled in 39 patients with depression, 40 patients with ME/CFS and 24 normal volunteers. Whole blood was analysed for GPX activity using the Ransel assay (Randox). Severity of illness was measured by means of the Hamilton Depression Rating Scale (HDRS) and the Fibromyalgia and Chronic Fatigue Syndrome Rating Scale (FF scale).
RESULTS: We found that whole blood GPX activity was significantly (p=0.001) lower in depressed patients than in normal controls and that there were no significant differences between ME/CFS and controls. In depression and ME/CFS, there were significant and inverse relationships between GPX activity and the FF items, depressed mood and autonomic symptoms. In depression, there were significant and negative correlations between whole blood GPX and the HDRS score and autonomic symptoms.
DISCUSSION: The results show that lowered whole blood GPX activity contributes to the lowered antioxidant status in depression. Since GPX activity is a predictor of neuroprogression and coronary artery disease (CAD), lowered GPX activity in depression contributes to the IN-PRO pathways and the comorbidity between depression and CAD. Our results suggest that patients with depression would benefit from Ebselen or a supplementation with glutathione, N-Acetyl-l-Cysteine and selenium.
Michael Maes; Ivanka Mihaylova; Marta Kubera; Marc Uytterhoeven; Nicolas Vrydags; Eugene Bosmans
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Neuro endocrinology letters     Volume:  32     ISSN:  0172-780X     ISO Abbreviation:  Neuro Endocrinol. Lett.     Publication Date:  2011  
Date Detail:
Created Date:  2011-07-01     Completed Date:  2011-09-08     Revised Date:  2013-09-20    
Medline Journal Info:
Nlm Unique ID:  8008373     Medline TA:  Neuro Endocrinol Lett     Country:  Sweden    
Other Details:
Languages:  eng     Pagination:  133-40     Citation Subset:  IM    
Piyavate Hospital, Bangkok, Thailand, Thailand.
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MeSH Terms
Antioxidants / metabolism
Biological Markers / blood
Case-Control Studies
Coronary Artery Disease / epidemiology,  physiopathology*
Depression / blood*,  epidemiology,  physiopathology*
Disease Progression
Fatigue Syndrome, Chronic / blood*,  physiopathology
Glutathione Peroxidase / blood*
Middle Aged
Severity of Illness Index
Signal Transduction / physiology*
Reg. No./Substance:
0/Antioxidants; 0/Biological Markers; EC Peroxidase

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