| Lower uterine artery blood flow and higher endothelin relative to nitric oxide metabolite levels are associated with reductions in birth weight at high altitude. | |
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MedLine Citation:
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PMID: 18579652 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Reduced uteroplacental blood flow is hypothesized to play a key role in altitude-associated fetal growth restriction. It is unknown whether reduced blood flow is a cause or consequence of reduced fetal size. We asked whether determinants of uteroplacental blood flow were altered prior to reduced fetal growth and whether vasoactive and/or angiogenic factors were involved. Women residing at low (LA; 1,600 m, n = 18) or high altitude (HA; 3,100 m, n = 25) were studied during pregnancy (20, 30, and 36 wk) and 4 mo postpartum (PP) using Doppler ultrasound. In each study, endothelin (ET-1), nitric oxide metabolites (NO(x)), soluble fms-like tyrosine kinase (sFlt-1) and placental growth factor (PlGF) levels were quantified. At HA, birth weights were lower (P < 0.01) and small-for-gestational age was more common (P < 0.05) compared with LA. HA was associated with lower uterine artery (UA) diameter (P < 0.01) and blood flow (P < 0.05). Altitude did not affect ET-1, sFlt-1 or PlGF; however, ET-1/NO(x) was greater and NO(x) lower during pregnancy and PP at HA vs. LA. ET-1/NO(x) was negatively associated with birth weight (20 wk, P < 0.01; 36 wk, P = 0.05) at LA and HA combined. At HA, UA blood flow (30 wk) was positively associated with birth weight (dagger). UA blood flow and ET-1/NO(x) levels accounted for 45% (20 wk) and 32% (30 wk) of birth weight variation at LA and HA combined, primarily attributed to effects at HA. We concluded that elevated ET-1/NO(x) and altered determinants of uteroplacental blood flow occur prior to altitude-associated reductions in fetal growth, and therefore, they are likely a cause rather than a consequence of smaller fetal size. |
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Authors:
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Colleen Glyde Julian; Henry L Galan; Megan J Wilson; Wendy Desilva; Darleen Cioffi-Ragan; Joel Schwartz; Lorna G Moore |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2008-06-25 |
Journal Detail:
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Title: American journal of physiology. Regulatory, integrative and comparative physiology Volume: 295 ISSN: 0363-6119 ISO Abbreviation: Am. J. Physiol. Regul. Integr. Comp. Physiol. Publication Date: 2008 Sep |
Date Detail:
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Created Date: 2008-09-08 Completed Date: 2008-10-17 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 100901230 Medline TA: Am J Physiol Regul Integr Comp Physiol Country: United States |
Other Details:
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Languages: eng Pagination: R906-15 Citation Subset: IM |
Affiliation:
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Altitude Research Center, Dept. of Surgery, Division of Emergency Medicine, Univ. of Colorado Denver, 12469 East 17th Place, Bldg. 400, Aurora, Colorado 80045, USA. colleen.julian@uchsc.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Altitude* Birth Weight / physiology* Colorado Endothelin-1 / metabolism* Female Femur / anatomy & histology Fetal Growth Retardation / metabolism*, physiopathology Head / anatomy & histology Humans Infant, Newborn Infant, Small for Gestational Age Nitric Oxide / metabolism* Oxygen / metabolism Pregnancy Regression Analysis Uterus / blood supply*, metabolism* |
| Grant Support | |
ID/Acronym/Agency:
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HL-060131/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Endothelin-1; 10102-43-9/Nitric Oxide; 7782-44-7/Oxygen |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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