Document Detail


Lower strength of the human posterior patellar tendon seems unrelated to mature collagen cross-linking and fibril morphology.
MedLine Citation:
PMID:  19892929     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The human patellar tendon is frequently affected by tendinopathy, but the etiology of the condition is not established, although differential loading of the anterior and posterior tendon may be associated with the condition. We hypothesized that changes in fibril morphology and collagen cross-linking would parallel differences in material strength between the anterior and posterior tendon. Tendon fascicles were obtained from elective ACL surgery patients and tested micromechanically. Transmission electron microscopy was used to assess fibril morphology, and collagen cross-linking was determined by HPLC and calorimetry. Anterior fascicles were markedly stronger (peak stress: 54.3 +/- 21.2 vs. 39.7 +/- 21.3 MPa; P < 0.05) and stiffer (624 +/- 232 vs. 362 +/- 170 MPa; P < 0.01) than posterior fascicles. Notably, mature pyridinium type cross-links were less abundant in anterior fascicles (hydroxylysylpyridinoline: 0.859 +/- 0.197 vs. 1.416 +/- 0.250 mol/mol, P = 0.001; lysylpyridinoline: 0.023 +/- 0.006 vs. 0.035 +/- 0.006 mol/mol, P < 0.01), whereas pentosidine and pyrrole concentrations showed no regional differences. Fibril diameters tended to be larger in anterior fascicles (7.819 +/- 2.168 vs. 4.897 +/- 1.434 nm(2); P = 0.10). Material properties did not appear closely related to cross-linking or fibril morphology. These findings suggest region-specific differences in mechanical, structural, and biochemical properties of the human patellar tendon.
Authors:
Philip Hansen; Bjarki Thor Haraldsson; Per Aagaard; Vuokko Kovanen; Nicholas C Avery; Klaus Qvortrup; Jytte Overgaard Larsen; Michael Krogsgaard; Michael Kjaer; S Peter Magnusson
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Publication Detail:
Type:  Journal Article     Date:  2009-11-05
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  108     ISSN:  1522-1601     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  2010 Jan 
Date Detail:
Created Date:  2010-01-07     Completed Date:  2010-03-17     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  47-52     Citation Subset:  IM    
Affiliation:
Institute of Sports Medicine Copenhagen, Bispebjerg Hospital & Center for Healthy Aging, University of Copenhagen, DK-2400 Copenhagen NV, Denmark.
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MeSH Terms
Descriptor/Qualifier:
Adult
Cross-Linking Reagents / chemistry
Fibrillar Collagens / chemistry,  physiology*,  ultrastructure*
Humans
Male
Patellar Ligament / chemistry,  physiology*,  ultrastructure*
Stress, Mechanical
Structure-Activity Relationship
Tensile Strength / physiology
Chemical
Reg. No./Substance:
0/Cross-Linking Reagents; 0/Fibrillar Collagens
Comments/Corrections
Erratum In:
J Appl Physiol. 2010 Mar;108(3):763

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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