| Lower prevalence of the OCT2 Ser270 allele in patients with essential hypertension. | |
| | |
MedLine Citation:
|
PMID: 17060063 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Impairment of the renal dopaminergic pathway has been shown to result in essential hypertension. The Organic Cation Transporter 2, OCT2 (SLC22A2), has been implicated in renal dopamine handling as well as in the inactivation of circulating catecholamines and is supposed to be involved in blood pressure regulation. This study investigated the association of the OCT2 Ala270Ser polymorphism with essential hypertension and its impact on blood pressure status in 607 Caucasian patients who underwent left heart catheterization. Clinical characteristics and diagnosis were recorded and blood pressure was determined by intravascular measurement. A comparison of genotypes revealed that patients with the Ser270 allele were less frequently affected by the clinical diagnosis of hypertension than homozygous carriers of the wild type allele Ala270 (Kruskal Wallis test, p = 0.028). This relation was even more pronounced in the subgroup of patients without diabetes mellitus (Kruskal Wallis test, p = 0.013). In summary, the first data on OCT2 are presented in the context of a candidate gene analysis. The Ala270Ser polymorphism was significantly associated with essential hypertension in the present sample. This study further suggests a function of OCT2 in blood pressure homeostasis and points to the potential role of the transporter in the development of essential hypertension. |
| | |
Authors:
|
Andreas Lazar; Tim Zimmermann; Werner Koch; Dirk Gründemann; Albert Schömig; Adnan Kastrati; Edgar Schömig |
Related Documents
:
|
16541193 - Cyp2c9 ile359leu polymorphism, plasma irbesartan concentration and acute blood pressure... 16405593 - Changes in genetic architecture during relaxation in drosophila melanogaster selected o... 2305583 - Early hemodynamic changes following selective distal splenorenal shunt for portal hyper... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Clinical and experimental hypertension (New York, N.Y. : 1993) Volume: 28 ISSN: 1064-1963 ISO Abbreviation: Clin. Exp. Hypertens. Publication Date: 2006 Oct |
Date Detail:
|
Created Date: 2006-10-24 Completed Date: 2006-11-14 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9305929 Medline TA: Clin Exp Hypertens Country: United States |
Other Details:
|
Languages: eng Pagination: 645-53 Citation Subset: IM |
Affiliation:
|
Department of Pharmacology, University of Cologne, Cologne, Germany. andreas.lazar@uk-koeln.de |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adolescent Adult Aged Aged, 80 and over Alleles Blood Pressure / genetics, physiology Case-Control Studies European Continental Ancestry Group / genetics Female Gene Frequency / genetics*, physiology Heart Catheterization Homeostasis / genetics, physiology Humans Hypertension / ethnology, etiology, genetics*, physiopathology Male Middle Aged Mutation / genetics Organic Cation Transport Proteins / genetics*, physiology Polymorphism, Genetic / genetics, physiology |
| Chemical | |
Reg. No./Substance:
|
0/Organic Cation Transport Proteins; 0/SLC22A2 protein, human |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Pharmacokinetics and safety of olmesartan medoxomil in combination with glibenclamide in healthy vol...
Next Document: Additional antihypertensive effect of drugs in hypertensive subjects uncontrolled on diltiazem monot...