Document Detail


Lower prevalence of the OCT2 Ser270 allele in patients with essential hypertension.
MedLine Citation:
PMID:  17060063     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Impairment of the renal dopaminergic pathway has been shown to result in essential hypertension. The Organic Cation Transporter 2, OCT2 (SLC22A2), has been implicated in renal dopamine handling as well as in the inactivation of circulating catecholamines and is supposed to be involved in blood pressure regulation. This study investigated the association of the OCT2 Ala270Ser polymorphism with essential hypertension and its impact on blood pressure status in 607 Caucasian patients who underwent left heart catheterization. Clinical characteristics and diagnosis were recorded and blood pressure was determined by intravascular measurement. A comparison of genotypes revealed that patients with the Ser270 allele were less frequently affected by the clinical diagnosis of hypertension than homozygous carriers of the wild type allele Ala270 (Kruskal Wallis test, p = 0.028). This relation was even more pronounced in the subgroup of patients without diabetes mellitus (Kruskal Wallis test, p = 0.013). In summary, the first data on OCT2 are presented in the context of a candidate gene analysis. The Ala270Ser polymorphism was significantly associated with essential hypertension in the present sample. This study further suggests a function of OCT2 in blood pressure homeostasis and points to the potential role of the transporter in the development of essential hypertension.
Authors:
Andreas Lazar; Tim Zimmermann; Werner Koch; Dirk Gründemann; Albert Schömig; Adnan Kastrati; Edgar Schömig
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical and experimental hypertension (New York, N.Y. : 1993)     Volume:  28     ISSN:  1064-1963     ISO Abbreviation:  Clin. Exp. Hypertens.     Publication Date:  2006 Oct 
Date Detail:
Created Date:  2006-10-24     Completed Date:  2006-11-14     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9305929     Medline TA:  Clin Exp Hypertens     Country:  United States    
Other Details:
Languages:  eng     Pagination:  645-53     Citation Subset:  IM    
Affiliation:
Department of Pharmacology, University of Cologne, Cologne, Germany. andreas.lazar@uk-koeln.de
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Aged, 80 and over
Alleles
Blood Pressure / genetics,  physiology
Case-Control Studies
European Continental Ancestry Group / genetics
Female
Gene Frequency / genetics*,  physiology
Heart Catheterization
Homeostasis / genetics,  physiology
Humans
Hypertension / ethnology,  etiology,  genetics*,  physiopathology
Male
Middle Aged
Mutation / genetics
Organic Cation Transport Proteins / genetics*,  physiology
Polymorphism, Genetic / genetics,  physiology
Chemical
Reg. No./Substance:
0/Organic Cation Transport Proteins; 0/SLC22A2 protein, human

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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