| Lower genital tract inflammatory milieu and the risk of subsequent preterm birth: an exploratory factor analysis. | |
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MedLine Citation:
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PMID: 21470267 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The inflammatory milieu of the cervix may play a role in preventing intrauterine infection and subsequent preterm birth. The objectives of this study were to use exploratory factor analysis to discover the underlying structure of cytokines in the lower genital tract immunological milieu, and evaluate the association between the cytokine factors and risk of preterm birth. Women (n=613) enrolled in a prospective pregnancy cohort study in Pittsburgh, Pennsylvania had cervical cytokine concentrations assayed at <16 weeks and were followed for data on pregnancy outcomes. Principal factor analysis identified two primary cytokine patterns at <16 weeks gestation: Factor 1 (pro-inflammatory/immunomodulatory factor), which loaded highly on interleukin (IL)-1β, IL-6, IL-8, monocyte chemotactic protein-1, and IL-10, and Factor 2 (anti-inflammatory factor), which loaded heavily on IL-4, IL-10, and IL-13. Women in the highest tertile of anti-inflammatory cytokine factor scores at <16 weeks had an increased risk of spontaneous preterm birth (confounder-adjusted odds ratio [95% confidence interval]: 2.4 [1.1, 5.7]). There was no association between pro-inflammatory cytokine factor scores and preterm birth risk. These data support the hypothesis that increased concentrations of anti-inflammatory cytokines may represent a cervical immune milieu that permits subsequent microbial invasion of the uterus during pregnancy, leading to subsequent spontaneous preterm birth. |
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Authors:
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Hyagriv N Simhan; Lisa M Bodnar; Kevin H Kim |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2011-03-21 |
Journal Detail:
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Title: Paediatric and perinatal epidemiology Volume: 25 ISSN: 1365-3016 ISO Abbreviation: Paediatr Perinat Epidemiol Publication Date: 2011 May |
Date Detail:
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Created Date: 2011-04-07 Completed Date: 2011-08-03 Revised Date: 2012-05-02 |
Medline Journal Info:
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Nlm Unique ID: 8709766 Medline TA: Paediatr Perinat Epidemiol Country: England |
Other Details:
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Languages: eng Pagination: 277-82 Citation Subset: IM |
Copyright Information:
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© 2011 Blackwell Publishing Ltd. |
Affiliation:
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Division of Maternal-Fetal Medicine, Department of Obstetrics, Gynecology, and Reproductive Sciences, Magee-Womens Hospital and University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. hsimhan@mwri.magee.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Cervix Uteri / immunology* Cytokines / analysis* Factor Analysis, Statistical Female Humans Obstetric Labor, Premature / immunology* Pennsylvania Pregnancy Prospective Studies Risk Factors Young Adult |
| Grant Support | |
ID/Acronym/Agency:
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L30 HD048015-02/HD/NICHD NIH HHS; R01 HD052732-01/HD/NICHD NIH HHS; R01HD041663/HD/NICHD NIH HHS; R01HD052732/HD/NICHD NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Cytokines |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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