Document Detail


Lower functional gastrointestinal disorders: evidence of abnormal colonic transit in a 287 patient cohort.
MedLine Citation:
PMID:  20025692     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND Abnormalities of colonic motility were reported in relatively small studies of patients with lower functional gastrointestinal disorders (FGID) including irritable bowel syndrome (IBS). The influence of gender and body mass on the observed motor pathophysiology is unclear. We sought to compare colonic transit in patients within different lower FGID subgroups and healthy controls, controlling for gender and BMI, and to determine whether BMI independently influences colonic motility. METHODS We evaluated a scintigraphic gastrointestinal and colonic transit database of 287 lower FGID patients associated with constipation (IBS-C, or functional constipation, n = 118), diarrhoea (IBS-D or functional diarrhoea, n = 139) or mixed bowel function (IBS-M, n = 30) and 170 healthy controls. We measured colon filling at 6 h (CF 6 h), and overall colonic transit at 8, 24 and 48 h. KEY RESULTS Colon filling at 6 h did not differentiate health from FGID. Colonic transit was abnormal at 24 h (GC24 of <1.50 or >3.86) in 29.7% of all lower FGID patients. There was a significant overall association between colonic transit and subject group (healthy controls and FGID subgroups) at 8 (P = 0.01), 24 (P < 0.001) and 48 h (P < 0.001) in particular for those with diarrhoea or constipation at 24 and 48 h (P < 0.05), even after adjusting for age, gender and BMI. In addition, BMI was associated with colonic transit after adjusting for age, gender and subject group. CONCLUSIONS & INFERENCES Abnormal transit is documented non-invasively with scintigraphy in 30% of lower FGID patients; transit measurement may help document pathophysiology and inform selection of therapy in lower FGID.
Authors:
N Manabe; B S Wong; M Camilleri; D Burton; S McKinzie; A R Zinsmeister
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2009-12-21
Journal Detail:
Title:  Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society     Volume:  22     ISSN:  1365-2982     ISO Abbreviation:  Neurogastroenterol. Motil.     Publication Date:  2010 Mar 
Date Detail:
Created Date:  2010-04-09     Completed Date:  2010-06-28     Revised Date:  2014-09-14    
Medline Journal Info:
Nlm Unique ID:  9432572     Medline TA:  Neurogastroenterol Motil     Country:  England    
Other Details:
Languages:  eng     Pagination:  293-e82     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Chi-Square Distribution
Cohort Studies
Colon / physiopathology*
Colonic Diseases, Functional / physiopathology*
Constipation / physiopathology
Female
Gastric Emptying / physiology
Gastrointestinal Transit / physiology*
Humans
Male
Patient Selection
Sex Factors
Grant Support
ID/Acronym/Agency:
R01 DK-54681/DK/NIDDK NIH HHS; R01 DK054681/DK/NIDDK NIH HHS; R01 DK054681-08/DK/NIDDK NIH HHS
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