| Lower extremity vasospasm associated with ischemic neuropathy, dermal fibrosis, and digital gangrene in a patient with carcinoid syndrome. | |
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MedLine Citation:
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PMID: 3409164 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Bilateral lower extremity vasospasm associated with severe pain and hyperesthesias in the legs, and digital gangrene in both feet developed in a 50-year-old man with carcinoid syndrome. Nifedipine and chemical lumbar sympathectomy were partially effective in relieving the vasospasm. Electromyographic findings were consistent with ischemic neuropathy. A skin biopsy specimen showed striking dermal fibrosis. Serotonin and other vasoconstrictor substances released from the tumor may be responsible for the vasospasm, the dermal sclerosis, and the ischemic neuropathy. The early use of lumbar sympathectomy in patients with lower extremity vasospasm may prevent these irreversible ischemic complications. |
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Authors:
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O Kucuk; G Noskin; K Petersen; E Ezdinli; D Rollins; S Singh; S Sarpel |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Cancer Volume: 62 ISSN: 0008-543X ISO Abbreviation: Cancer Publication Date: 1988 Sep |
Date Detail:
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Created Date: 1988-09-28 Completed Date: 1988-09-28 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0374236 Medline TA: Cancer Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1026-9 Citation Subset: AIM; IM |
Affiliation:
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Department of Medicine, University of Health Sciences, Chicago Medical School, IL 60064. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Bronchial Neoplasms
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physiopathology* Carcinoid Tumor / physiopathology* Cardiovascular Diseases / complications* Fibrosis Gangrene / complications Humans Leg / blood supply Liver Neoplasms / secondary Male Middle Aged Skin Diseases / complications* Syndrome Vasoconstrictor Agents / blood |
| Chemical | |
Reg. No./Substance:
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0/Vasoconstrictor Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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