| Lower exhaled nitric oxide in hypobaric than in normobaric acute hypoxia. | |
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MedLine Citation:
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PMID: 19686871 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Analysis of exhaled nitric oxide (NO) has become an accepted complementary tool in the management of inflammatory airway diseases. Previous studies have demonstrated reduced exhaled NO at altitude and ascribed their findings to hypoxia. We studied exhaled NO partial pressures (Pe(NO)) in eight healthy subjects at reduced ambient pressure down to 540 hPa (equivalent to 5000 m altitude) and at sea level, with equivalently hypoxic breathing gases (down to 11.3% O2 in N2). Pe(NO) readings were corrected for gas density effects on the instrument performance. Sea level control values for Pe(NO) at an exhaled flow of 50 mls(-1) averaged 2.4 mPa and were virtually unchanged with normobaric hypoxia down to an inspired P(O)(2) of 10.7 kPa. With the same degree of hypoxia, hypobaric Pe(NO) was 1.4 mPa. The reduction in hypobaric Pe(NO) of up to 33+/-16% (mean+/-SD) in comparison to normobaric Pe(NO), is likely to have been caused by enhanced axial back diffusion of NO because of the reduced gas density and an associated increased alveolar NO uptake to the blood. |
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Authors:
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Tryggve Hemmingsson; Dag Linnarsson |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-08-15 |
Journal Detail:
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Title: Respiratory physiology & neurobiology Volume: 169 ISSN: 1878-1519 ISO Abbreviation: Respir Physiol Neurobiol Publication Date: 2009 Oct |
Date Detail:
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Created Date: 2009-10-05 Completed Date: 2009-12-09 Revised Date: 2010-04-16 |
Medline Journal Info:
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Nlm Unique ID: 101140022 Medline TA: Respir Physiol Neurobiol Country: Netherlands |
Other Details:
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Languages: eng Pagination: 74-7 Citation Subset: IM |
Affiliation:
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Section of Environmental Physiology, Department of Physiology and Pharmacology, Karolinska Institutet, SE-171 77 Stockholm, Sweden. tryggve.hemmingsson@ki.se |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Altitude Anoxia / physiopathology* Female Humans Male Nitric Oxide / blood* Oxygen / blood Partial Pressure Respiratory Mechanics / physiology* |
| Chemical | |
Reg. No./Substance:
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10102-43-9/Nitric Oxide; 7782-44-7/Oxygen |
| Comments/Corrections | |
Comment In:
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Respir Physiol Neurobiol. 2010 Mar 31;170(3):211-2; author reply 213-4
[PMID:
20123043
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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