Document Detail

Lower excess postexercise oxygen consumption and altered growth hormone and cortisol responses to exercise in obese men.
MedLine Citation:
PMID:  16332937     Owner:  NLM     Status:  MEDLINE    
CONTEXT: Obesity is associated with altered patterns of substrate utilization at rest and during exercise. OBJECTIVE: The relationship between obesity and fat oxidation during recovery from exercise was examined. HYPOTHESIS: The postexercise shift toward fat oxidation is blunted in the obese state, reflected by higher respiratory exchange ratio (RER), blunted GH, and increased cortisol values compared with lean controls. DESIGN: Each subject completed two 160-min protocols (baseline and exercise). During baseline, subjects rested for 160 min; during exercise, they completed 30 min of cycling at ventilatory threshold, followed by 130 min of rest. SETTING: This study was performed at the University of Alberta. SUBJECTS: Healthy untrained (maximal oxygen consumption, <45 ml/kg.min or <3.35 liter/min) lean (<16% body fat; n = 6) and obese (>25% body fat; n = 7) men, aged 30-39 yr, were studied. MAIN OUTCOME MEASURES: RER, GH, cortisol, oxygen consumption, heart rate, tympanic temperature, and lactate were obtained during both protocols at matched time intervals and analyzed by repeated measures ANOVA. RESULTS: During baseline, there were no differences detected between lean and obese groups for any of the measured variables. In contrast, during exercise, peak GH levels were blunted (P < 0.05) and cortisol levels were elevated (P < 0.05) in the obese compared with the lean subjects, but RER values were similar in the two groups. The differences in GH and cortisol persisted during the postexercise period accompanied by higher RER values (P < 0.05) and reduced total oxygen consumption (P < 0.05) in the obese group. CONCLUSION: These findings indicate that exercise-induced fat oxidation is diminished in obese men.
Tina Wong; Vicki Harber
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Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2005-12-06
Journal Detail:
Title:  The Journal of clinical endocrinology and metabolism     Volume:  91     ISSN:  0021-972X     ISO Abbreviation:  J. Clin. Endocrinol. Metab.     Publication Date:  2006 Feb 
Date Detail:
Created Date:  2006-02-07     Completed Date:  2006-03-14     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0375362     Medline TA:  J Clin Endocrinol Metab     Country:  United States    
Other Details:
Languages:  eng     Pagination:  678-86     Citation Subset:  AIM; IM    
Faculty of Physical Education and Recreation, University of Alberta, E-424 Van Vliet Center, Edmonton, Alberta, Canada T6G 2H9.
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MeSH Terms
Body Temperature / physiology
Exercise / physiology*
Heart Rate / physiology
Human Growth Hormone / blood*
Hydrocortisone / blood*
Lactic Acid / blood
Obesity / blood,  metabolism*,  physiopathology
Oxygen Consumption / physiology*
Reg. No./Substance:
12629-01-5/Human Growth Hormone; 50-21-5/Lactic Acid; 50-23-7/Hydrocortisone

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