| Lower esophageal sphincter tone during reversal of neuromusclar blockade by atropine and neostigmine. | |
| | |
MedLine Citation:
|
PMID: 565153 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The effect on lower esophageal sphincter (LES) pressure of IV atropine and neostigmine, a drug combination routinely given to antagonize nondepolarizing neuromusclar blockade at the end of a general anesthetic, was studied in 22 patients undergoing cesarean section. Atropine 1.2 mg and neostigmine 2.5 mg IV decreased LES pressure insignificantly by a mean of 0.7 kPa (p less than 0.1). In contrast, atropine 1.2 mg and neostigmine 5 mg increased LES pressure by a mean of 1.4 kPa (p less than 0.001). The latter dosage of this drug combination, therefore, appears preferable in patients presenting for emergency surgery if the integrity of the lower esophageal sphincter is to be maintained during extubation and recovery from general anesthesia. |
| | |
Authors:
|
J G Brock-Utne; J W Downing; S Welman; G E Dimopoulos; M G Moshal |
Related Documents
:
|
1254133 - Manometric studies of the human pylorus. 3195543 - Induction of lower esophageal sphincter (les) dysfunction during use of the negative pr... 1536063 - A system for saturating in vitro preparations with high pressure o2, he, h2, and mixtures. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Anesthesia and analgesia Volume: 57 ISSN: 0003-2999 ISO Abbreviation: Anesth. Analg. Publication Date: 1978 Mar-Apr |
Date Detail:
|
Created Date: 1978-05-20 Completed Date: 1978-05-20 Revised Date: 2004-11-17 |
Medline Journal Info:
|
Nlm Unique ID: 1310650 Medline TA: Anesth Analg Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 171-4 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Anesthesia, General Atropine / pharmacology* Cesarean Section Drug Therapy, Combination Esophagogastric Junction / drug effects* Female Humans Muscle Tonus / drug effects* Neostigmine / pharmacology Pregnancy |
| Chemical | |
Reg. No./Substance:
|
51-55-8/Atropine; 59-99-4/Neostigmine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Venous air embolism: comparative merits of external cardiac massage, intracardiac aspiration, and le...
Next Document: Comparison of anesthetic solutions used in lumbar and caudal peridural anesthesia.