Document Detail

Lower esophageal sphincter pressure, acid secretion, and blood gastrin after coffee consumption.
MedLine Citation:
PMID:  1551346     Owner:  NLM     Status:  MEDLINE    
This study tested the hypothesis that differences in the processing of raw coffee beans can account for some of the variability in gastric effects of coffee drinking. Coffees were selected to represent several ways that green coffee beans are treated, ie, processing variables. These included instant and ground coffee processing, decaffeination method (ethyl acetate or methylene chloride extraction), instant coffee processing temperature (112 degrees F or 300 degrees F), and steam treatment. Lower esophageal sphincter pressure, acid secretion, and blood gastrin was measured in eight human subjects after they consumed each of the different coffees. Consumption of coffee was followed by a sustained decrease in lower esophageal sphincter pressure (P less than 0.05) except for three of the four coffees treated with ethyl acetate regardless of whether or not they contained caffeine. Caffeinated ground coffee stimulated more acid secretion that did decaf ground coffees (P less than 0.05), but not more than a steam-treated caffeinated coffee. Instant coffees did not differ in acid-stimulating ability. Ground caffeinated coffee resulted in higher blood gastrin levels than other ground coffees (P less than 0.05). Freeze-dried instant coffee also tended toward higher gastrin stimulation. It is concluded that some of the observed variability in gastric response to coffee consumption can be traced to differences in how green coffee beans are processed.
G Van Deventer; E Kamemoto; J T Kuznicki; D C Heckert; M C Schulte
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Digestive diseases and sciences     Volume:  37     ISSN:  0163-2116     ISO Abbreviation:  Dig. Dis. Sci.     Publication Date:  1992 Apr 
Date Detail:
Created Date:  1992-04-27     Completed Date:  1992-04-27     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7902782     Medline TA:  Dig Dis Sci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  558-69     Citation Subset:  AIM; IM    
Center for Ulcer Research and Education, Los Angeles, California.
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MeSH Terms
Analysis of Variance
Caffeine / blood
Coffee / adverse effects*
Esophagogastric Junction / physiology*
Gastric Acid / secretion*
Gastrins / blood*
Reference Values
Reg. No./Substance:
0/Coffee; 0/Gastrins; 58-08-2/Caffeine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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