| Lower esophageal sphincter analysis using computerized manometry in patients with chagasic megaesophagus. | |
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MedLine Citation:
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PMID: 16364041 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Due to the introduction of computer technology into manometry laboratories, three-dimensional manometric images of the lower esophageal sphincter can be constructed based on radially oriented pressures, a method termed 'computerized axial manometry.' Calculation of the sphincter pressure vector volume using this method is superior to standard manometric techniques in assessing lower esophageal sphincter function in patients with gastroesophageal reflux disease and idiopathic achalasia. Despite similarities between idiopathic achalasia and chagasic esophagopathy found using clinical, radiological, and manometric studies, controversy around lower esophageal sphincter pressure persists. The goal of this study was to analyze esophageal motor disorders in Chagas' megaesophagus using computerized axial manometry. Twenty patients with chagasic megaesophagus (5 men, 15 women, and average age 50.1 years, range 17-64) were prospectively studied. For three-dimensional imaging construction of the lower esophageal sphincter, a low-complacency perfusion system and an eight-channel manometry probe with four radial channels placed in the same level were used. For probe traction, the continuous pull-through technique was used. Results showed that the lower esophageal sphincter of patients with chagasic megaesophagus have significantly elevated pressure, length, asymmetry, and vector volumes compared to those of normal volunteers (P < 0.05). Aperistalsis of the esophageal body waves was observed in all patients and contraction amplitude was lower than that in normal patients. We conclude that patients with chagasic megaesophagus have hypertonic lower esophageal sphincter and aperistalsis of the esophageal body. |
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Authors:
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C G Andrade; I Cecconello; A Nasi; B Zilberstein; J R Filho; P J Campos Carvalho; P Donahue; J J Gama-Rodrigues |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus / I.S.D.E Volume: 19 ISSN: 1120-8694 ISO Abbreviation: Dis. Esophagus Publication Date: 2006 |
Date Detail:
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Created Date: 2005-12-20 Completed Date: 2006-12-19 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8809160 Medline TA: Dis Esophagus Country: Australia |
Other Details:
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Languages: eng Pagination: 31-5 Citation Subset: IM |
Affiliation:
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Department Of Gastroenterology, University Of São Paulo Medical School, São Paulo, Brazil. cg-andrade@uol.com.br |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Chagas Disease / diagnosis, physiopathology* Esophageal Achalasia / diagnosis, physiopathology* Esophageal Sphincter, Lower / physiopathology* Female Gastroesophageal Reflux / physiopathology Humans Imaging, Three-Dimensional / instrumentation Male Manometry / instrumentation* Middle Aged Prospective Studies |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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