Document Detail

Lower embryonic loss rates among twin gestations following assisted reproduction.
MedLine Citation:
PMID:  16047578     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To determine whether maternal age and number of transferred embryos influence early pregnancy losses in twin pregnancies compared to singletons following IVF/ICSI.
METHODS: We compared the pregnancy loss rates in singleton (n = 549) and twin (n = 252) gestations, stratified by maternal age (< or = 35 and > 35 years) and the number of transferred embryos (1-3 and 4-9).
RESULTS: Loss rates of singleton pregnancies were significantly higher than that in twins (OR 3.0, 95% CI 1.9, 4.9), especially among singletons conceived after transfer of 4-9 embryos (OR 5.0, 95% CI 2.2, 11.9). Younger mothers of twins had lower loss rates (OR 0.3, 95% CI 0.1, 0.9).
CONCLUSION: Twins have a significantly reduced spontaneous miscarriage rate compared with singletons following IVF/ICSI. Higher implantation rates per cycle (i.e., development of twins rather than one live embryo) may represent a better capacity of the uterus for early embryonic development.
G B La Sala; G Nucera; A Gallinelli; A Nicoli; M T Villani; I Blickstein
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of assisted reproduction and genetics     Volume:  22     ISSN:  1058-0468     ISO Abbreviation:  J. Assist. Reprod. Genet.     Publication Date:  2005 May 
Date Detail:
Created Date:  2005-07-28     Completed Date:  2005-09-13     Revised Date:  2013-02-19    
Medline Journal Info:
Nlm Unique ID:  9206495     Medline TA:  J Assist Reprod Genet     Country:  United States    
Other Details:
Languages:  eng     Pagination:  181-4     Citation Subset:  IM    
Department of Obstetrics and Gynecolgy, Arcispedale Santa Maria Nuova, Reggio Emilia, Italy.
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MeSH Terms
Abortion, Spontaneous / etiology*
Embryonic Development / physiology
Maternal Age
Pregnancy Trimester, First
Pregnancy, Multiple*
Prospective Studies
Sperm Injections, Intracytoplasmic / adverse effects*

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