| Lower bone mineral content in hypertensive compared with normotensive overweight Latino children and adolescents. | |
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MedLine Citation:
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PMID: 17261466 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: In adults, hypertension has been shown to be inversely correlated with bone mineral content (BMC); however, the association between blood pressure (BP) and BMC has not been studied in pediatrics. METHODS: Total body BMC of 187 overweight (mean BMI = 28.7 kg/m(2)) Latino children and adolescents (mean age = 11.2 years) were measured using dual-energy x-ray absorptiometry. Seated systolic BP (SBP) and diastolic BP (DBP) were measured using a standard mercury sphygmomanometer. Hypertension was defined by SBP or DBP above the 90(th) percentile for height, age, and sex. RESULTS: Partial correlations revealed an inverse association between SBP and BMC (r = -0.24, P = 0.02) in boys (n = 105); results were nonsignificant (P = 0.27) in girls (n = 82). There were no significant correlations between DBP and BMC. When BMI and insulin sensitivity were adjusted for, hypertensive boys (n = 21) had lower BMC (1435 v 1636 g; P = 0.03) than normotensive boys (n = 84); similarly, hypertensive girls (n = 25) had lower BMC (1438 v 1618 g; P = 0.02) than normotensive girls (n = 57). In postpubertal adolescents (Tanner stage 4-5; n = 48), inverse correlations were stronger (r = -0.40, P = 0.007); results were nonsignificant in prepubertal and pubertal children (Tanner stage 1-3; n = 139, P = 0.57). In postpubertal girls (n = 37), there were no significant correlations (P = 0.14); inverse correlations in postpubertal boys (n = 11) became markedly stronger (r = -0.80, P = 0.02). CONCLUSION: Based on the study findings, SBP is inversely correlated with BMC in overweight adolescents; additionally, hypertensive subjects have lower adjusted means of BMC than normotensive subjects. These promising new findings suggest that hypertension may be a risk factor for osteopenia in overweight children and adolescents; this risk may be exacerbated in postpubertal boys. |
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Authors:
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Afrooz Afghani; Michael I Goran |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
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Title: American journal of hypertension Volume: 20 ISSN: 0895-7061 ISO Abbreviation: Am. J. Hypertens. Publication Date: 2007 Feb |
Date Detail:
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Created Date: 2007-01-30 Completed Date: 2007-05-07 Revised Date: 2013-06-06 |
Medline Journal Info:
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Nlm Unique ID: 8803676 Medline TA: Am J Hypertens Country: United States |
Other Details:
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Languages: eng Pagination: 190-6 Citation Subset: IM |
Affiliation:
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Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA. aafghani@tourou.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Blood Pressure* Blood Pressure Determination Bone Density* Bone Diseases, Metabolic / epidemiology* California / epidemiology, ethnology Child Female Hispanic Americans Humans Hypertension / complications, metabolism* Male Overweight* Risk Factors |
| Grant Support | |
ID/Acronym/Agency:
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M01 RR 00043/RR/NCRR NIH HHS; R01 DK 59211/DK/NIDDK NIH HHS; R01 DK059211-07/DK/NIDDK NIH HHS |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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