Document Detail


Lower bone mineral content in hypertensive compared with normotensive overweight Latino children and adolescents.
MedLine Citation:
PMID:  17261466     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: In adults, hypertension has been shown to be inversely correlated with bone mineral content (BMC); however, the association between blood pressure (BP) and BMC has not been studied in pediatrics.
METHODS: Total body BMC of 187 overweight (mean BMI = 28.7 kg/m(2)) Latino children and adolescents (mean age = 11.2 years) were measured using dual-energy x-ray absorptiometry. Seated systolic BP (SBP) and diastolic BP (DBP) were measured using a standard mercury sphygmomanometer. Hypertension was defined by SBP or DBP above the 90(th) percentile for height, age, and sex.
RESULTS: Partial correlations revealed an inverse association between SBP and BMC (r = -0.24, P = 0.02) in boys (n = 105); results were nonsignificant (P = 0.27) in girls (n = 82). There were no significant correlations between DBP and BMC. When BMI and insulin sensitivity were adjusted for, hypertensive boys (n = 21) had lower BMC (1435 v 1636 g; P = 0.03) than normotensive boys (n = 84); similarly, hypertensive girls (n = 25) had lower BMC (1438 v 1618 g; P = 0.02) than normotensive girls (n = 57). In postpubertal adolescents (Tanner stage 4-5; n = 48), inverse correlations were stronger (r = -0.40, P = 0.007); results were nonsignificant in prepubertal and pubertal children (Tanner stage 1-3; n = 139, P = 0.57). In postpubertal girls (n = 37), there were no significant correlations (P = 0.14); inverse correlations in postpubertal boys (n = 11) became markedly stronger (r = -0.80, P = 0.02).
CONCLUSION: Based on the study findings, SBP is inversely correlated with BMC in overweight adolescents; additionally, hypertensive subjects have lower adjusted means of BMC than normotensive subjects. These promising new findings suggest that hypertension may be a risk factor for osteopenia in overweight children and adolescents; this risk may be exacerbated in postpubertal boys.
Authors:
Afrooz Afghani; Michael I Goran
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  American journal of hypertension     Volume:  20     ISSN:  0895-7061     ISO Abbreviation:  Am. J. Hypertens.     Publication Date:  2007 Feb 
Date Detail:
Created Date:  2007-01-30     Completed Date:  2007-05-07     Revised Date:  2013-06-06    
Medline Journal Info:
Nlm Unique ID:  8803676     Medline TA:  Am J Hypertens     Country:  United States    
Other Details:
Languages:  eng     Pagination:  190-6     Citation Subset:  IM    
Affiliation:
Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA. aafghani@tourou.edu
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Blood Pressure*
Blood Pressure Determination
Bone Density*
Bone Diseases, Metabolic / epidemiology*
California / epidemiology,  ethnology
Child
Female
Hispanic Americans
Humans
Hypertension / complications,  metabolism*
Male
Overweight*
Risk Factors
Grant Support
ID/Acronym/Agency:
M01 RR 00043/RR/NCRR NIH HHS; R01 DK 59211/DK/NIDDK NIH HHS; R01 DK059211-07/DK/NIDDK NIH HHS
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