| Lower blood pressure associated with higher mortality in elderly diabetic patients (ZODIAC-12). | |
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MedLine Citation:
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PMID: 20621928 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: to investigate the relationship between blood pressure over time and mortality in elderly patients with type 2 diabetes mellitus (T2DM). DESIGN: prospective observational cohort study. SETTING: primary care, Zwolle, The Netherlands. SUBJECTS: patients with T2DM aged 60 years and older (n = 881). The cohort was divided into two age categories: 60-75 years and older than 75 years. METHODS: updated means for systolic, diastolic and pulse pressures were calculated after a median follow-up time of 9.8 years. These values were used as time-dependent covariates in a Cox proportional hazard model. Main outcome measures were all-cause and cardiovascular mortality. RESULTS: all of the blood pressure measures were inversely related to all-cause mortality in elderly diabetic patients (>75 years). Furthermore, these relationships were specifically found in elderly patients treated with antihypertensive medication at baseline. A decrease of 10 mm Hg in systolic blood pressure, diastolic blood pressure and pulse pressure led to a mortality increase of 22% [95% confidence interval (95% CI): 13-31%], 30% [95% CI: 13%-46%] and 22% [95% CI: 11%-33%], respectively. In the low age group (60-75 years), no relationship was found between blood pressure and mortality. CONCLUSIONS: blood pressure is a marker for mortality in elderly T2DM patients; however, the relationship is inverse. |
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Authors:
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Kornelis J J van Hateren; Gijs W D Landman; Nanne Kleefstra; Klaas H Groenier; Adriaan M Kamper; Sebastiaan T Houweling; Henk J G Bilo |
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Publication Detail:
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Type: Journal Article Date: 2010-07-09 |
Journal Detail:
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Title: Age and ageing Volume: 39 ISSN: 1468-2834 ISO Abbreviation: Age Ageing Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-08-18 Completed Date: 2010-11-30 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0375655 Medline TA: Age Ageing Country: England |
Other Details:
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Languages: eng Pagination: 603-9 Citation Subset: IM |
Affiliation:
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Diabetes Centre, Isala Clinics, Zwolle, The Netherlands. k.j.j.van.hateren@isala.nl |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aged, 80 and over Antihypertensive Agents / therapeutic use Blood Pressure* Diabetes Mellitus, Type 2 / mortality* Female Humans Hypertension / drug therapy, mortality* Male Middle Aged Netherlands / epidemiology Proportional Hazards Models Prospective Studies Risk Factors |
| Chemical | |
Reg. No./Substance:
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0/Antihypertensive Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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