| Low yield of routine screening for thyroid dysfunction in asymptomatic vitiligo patients. | |
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MedLine Citation:
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PMID: 22050082 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Background: Non-segmental vitiligo is considered to be an autoimmune disease and is known to be associated with other autoimmune diseases, particularly affecting the thyroid. Screening non-segmental vitiligo patients for thyroid function and for the presence of thyroid autoantibodies has been recommended. Objective: To investigate the prevalence of thyroid dysfunction and thyroid peroxidase-specific (TPO) antibodies in a large cohort of patients with non-segmental vitiligo in order to help decide whether routine screening is justified. Methods: 434 adults with non-segmental vitiligo who were referred to our institute were enrolled. Thyroid function and anti-TPO antibody titers were assessed in those patients who had no history of thyroid disease or recent thyroid screening. Results: Forty-three patients were already diagnosed with thyroid dysfunction and in 27 patients the general practitioner performed a thyroid function test with negative results less than three months ago. In these patients, thyroid function assessment was not repeated. The remaining 364 patients were screened for thyroid dysfunction. Overt hypothyroidism was newly diagnosed in 3 (0.8%) patients. Subclinical disease was found in 10 (2.7%) patients and increased levels of TPO-antibodies, without thyroid disease, were found in 49 (13.5%) patients. Elevated risk for thyroid disease was found among older women and in women with a positive family history for thyroid disease. Conclusion: The overall prevalence of thyroid dysfunction in adult patients with non-segmental vitiligo was higher than reported in the general population. However, the number of newly diagnosed cases with overt and subclinical thyroid dysfunction in our population was low. Most patients were already diagnosed by their general practitioner and had symptoms indicative for thyroid disease. Thyroid disease predominantly was found among older women and in persons with a positive family history for thyroid disease. Thyroid screening including anti-TPO antibodies is advisable in these high risk subpopulations. |
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Authors:
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M W Kroon; I C K W Joore; B S Wind; M A C Leloup; A Wolkerstorfer; R M Luiten; J D Bos; R B Geskus; J P W van der Veen |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-11-2 |
Journal Detail:
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Title: The British journal of dermatology Volume: - ISSN: 1365-2133 ISO Abbreviation: - Publication Date: 2011 Nov |
Date Detail:
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Created Date: 2011-11-4 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0004041 Medline TA: Br J Dermatol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 British Association of Dermatologists. |
Affiliation:
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Netherlands Institute for Pigment Disorders, Academic Medical Centre, University of Amsterdam, NL-1105AZ, Amsterdam, the Netherlands Department of Dermatology, Academic Medical Centre, University of Amsterdam, NL-1100DD, Amsterdam, the Netherlands Department of Clinical Epidemiology, Biostatistics and Bioinformatics, Academic Medical Centre, University of Amsterdam, NL-1105AZ, Amsterdam, the Netherlands The Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital (NKI-AVL), NL-1006BE, Amsterdam, the Netherlands. |
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