Document Detail

Low vs. higher-dose dark chocolate and blood pressure in cardiovascular high-risk patients.
MedLine Citation:
PMID:  20203627     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Dark chocolate may have blood pressure-lowering properties. We conducted a prospective randomized open-label blinded end-point design trial to study a potential dose dependency of the presumed antihypertensive effect of dark chocolate by directly comparing low vs. higher doses of dark chocolate over the course of 3 months.
METHODS: We enrolled a total of 102 patients with prehypertension/stage 1 hypertension and established cardiovascular end-organ damage or diabetes mellitus. Patients were randomly assigned to receive either 6 or 25 g/day of flavanol-rich dark chocolate for 3 months. The difference in 24-h mean blood pressure between groups was defined as the primary outcome measure.
RESULTS: Significant reductions in mean ambulatory 24-h blood pressure were observed between baseline and follow-up in both groups (6 g/day: -2.3 mm Hg, 95% confidence interval -4.1 to -0.4; 25 g/day: -1.9 mm Hg, 95% confidence interval -3.6 to -0.2). There were no significant differences in blood pressure changes between groups. In the higher-dose group, a slight increase in body weight was noted (0.8 kg, 95% confidence interval 0.06 to 1.6).
CONCLUSIONS: The findings are consistent with the hypothesis that dark chocolate may be associated with a reduction in blood pressure (BP). However, due to the lack of a control group, confounding may be possible and the results should be interpreted with caution.
Steffen Desch; Daniela Kobler; Johanna Schmidt; Melanie Sonnabend; Volker Adams; Mahdi Sareban; Ingo Eitel; Matthias Blüher; Gerhard Schuler; Holger Thiele
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial     Date:  2010-03-04
Journal Detail:
Title:  American journal of hypertension     Volume:  23     ISSN:  1941-7225     ISO Abbreviation:  Am. J. Hypertens.     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-05-18     Completed Date:  2010-08-20     Revised Date:  2011-06-30    
Medline Journal Info:
Nlm Unique ID:  8803676     Medline TA:  Am J Hypertens     Country:  United States    
Other Details:
Languages:  eng     Pagination:  694-700     Citation Subset:  IM    
Department of Cardiology, University of Leipzig-Heart Center, Leipzig, Germany.
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MeSH Terms
Blood Pressure / drug effects*
Blood Pressure Monitoring, Ambulatory
Cardiovascular Diseases / etiology
Diabetes Complications / physiopathology
Hypertension / complications,  drug therapy*

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