| Low vs. higher-dose dark chocolate and blood pressure in cardiovascular high-risk patients. | |
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MedLine Citation:
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PMID: 20203627 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Dark chocolate may have blood pressure-lowering properties. We conducted a prospective randomized open-label blinded end-point design trial to study a potential dose dependency of the presumed antihypertensive effect of dark chocolate by directly comparing low vs. higher doses of dark chocolate over the course of 3 months. METHODS: We enrolled a total of 102 patients with prehypertension/stage 1 hypertension and established cardiovascular end-organ damage or diabetes mellitus. Patients were randomly assigned to receive either 6 or 25 g/day of flavanol-rich dark chocolate for 3 months. The difference in 24-h mean blood pressure between groups was defined as the primary outcome measure. RESULTS: Significant reductions in mean ambulatory 24-h blood pressure were observed between baseline and follow-up in both groups (6 g/day: -2.3 mm Hg, 95% confidence interval -4.1 to -0.4; 25 g/day: -1.9 mm Hg, 95% confidence interval -3.6 to -0.2). There were no significant differences in blood pressure changes between groups. In the higher-dose group, a slight increase in body weight was noted (0.8 kg, 95% confidence interval 0.06 to 1.6). CONCLUSIONS: The findings are consistent with the hypothesis that dark chocolate may be associated with a reduction in blood pressure (BP). However, due to the lack of a control group, confounding may be possible and the results should be interpreted with caution. |
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Authors:
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Steffen Desch; Daniela Kobler; Johanna Schmidt; Melanie Sonnabend; Volker Adams; Mahdi Sareban; Ingo Eitel; Matthias Blüher; Gerhard Schuler; Holger Thiele |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial Date: 2010-03-04 |
Journal Detail:
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Title: American journal of hypertension Volume: 23 ISSN: 1941-7225 ISO Abbreviation: Am. J. Hypertens. Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-05-18 Completed Date: 2010-08-20 Revised Date: 2011-06-30 |
Medline Journal Info:
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Nlm Unique ID: 8803676 Medline TA: Am J Hypertens Country: United States |
Other Details:
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Languages: eng Pagination: 694-700 Citation Subset: IM |
Affiliation:
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Department of Cardiology, University of Leipzig-Heart Center, Leipzig, Germany. stdesch@web.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Blood Pressure
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drug effects* Blood Pressure Monitoring, Ambulatory Cacao* Candy Cardiovascular Diseases / etiology Diabetes Complications / physiopathology Female Humans Hypertension / complications, drug therapy* Male Risk |
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