| Low-volume ventilation causes peripheral airway injury and increased airway resistance in normal rabbits. | |
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MedLine Citation:
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PMID: 11842025 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Lung mechanics and morphometry of 10 normal open-chest rabbits (group A), mechanically ventilated (MV) with physiological tidal volumes (8-12 ml/kg), at zero end-expiratory pressure (ZEEP), for 3-4 h, were compared with those of five rabbits (group B) after 3-4 h of MV with a positive end-expiratory pressure (PEEP) of 2.3 cmH(2)O. Relative to initial MV on PEEP, MV on ZEEP caused a progressive increase in quasi-static elastance (+36%) and airway (Rint; +71%) and viscoelastic resistance (+29%), with no change in the viscoelastic time constant. After restoration of PEEP, quasi-static elastance and viscoelastic resistance returned to control levels, whereas Rint remained elevated (+22%). On PEEP, MV had no effect on lung mechanics. Gas exchange on PEEP was equally preserved in groups A and B, and the lung wet-to-dry ratios were normal. Both groups had normal alveolar morphology, whereas only group A had injured respiratory and membranous bronchioles. In conclusion, prolonged MV on ZEEP induces histological evidence of peripheral airway injury with a concurrent increase in Rint, which persists after restoration of normal end-expiratory volumes. This is probably due to cyclic opening and closing of peripheral airways on ZEEP. |
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Authors:
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Edgardo D'Angelo; Matteo Pecchiari; Paolo Baraggia; Marina Saetta; Elisabetta Balestro; Joseph Milic-Emili |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of applied physiology (Bethesda, Md. : 1985) Volume: 92 ISSN: 8750-7587 ISO Abbreviation: J. Appl. Physiol. Publication Date: 2002 Mar |
Date Detail:
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Created Date: 2002-02-13 Completed Date: 2002-05-07 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 8502536 Medline TA: J Appl Physiol Country: United States |
Other Details:
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Languages: eng Pagination: 949-56 Citation Subset: IM |
Affiliation:
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Istituto di Fisiologia Umana I, Università di Milano, 20133 Milan, Italy. edgardo.dangelo@unimi.it |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Airway Resistance* Animals Bronchi / pathology* Bronchial Diseases / etiology*, pathology, physiopathology* Elasticity Lung Volume Measurements Positive-Pressure Respiration Pressure Rabbits Reference Values Respiratory Physiological Phenomena* Viscosity |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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