Document Detail

Low vitamin d levels predict stroke in patients referred to coronary angiography.
MedLine Citation:
PMID:  18635847     Owner:  NLM     Status:  MEDLINE    
BACKGROUND AND PURPOSE: Vitamin D deficiency is common among the elderly and may contribute to cerebrovascular diseases. We aimed to elucidate whether low vitamin D levels are predictive for fatal stroke. METHODS: The LUdwigshafen RIsk and Cardiovascular Health (LURIC) study includes 3316 patients who were referred to coronary angiography at baseline between 1997 and 2000. 25-Hydroxyvitamin D [25(OH)D] and 1,25-dihydroxyvitamin D [1,25(OH)2D] were measured in 3299 and 3315 study participants, respectively. To account for the seasonal variation of vitamin D metabolites, we calculated z values for the 25(OH)D and 1,25(OH)2D concentrations within each month of blood draw. RESULTS: During a median follow-up time of 7.75 years, 769 patients died, including 42 fatal (ischemic and hemorrhagic) strokes. When compared with survivors in binary logistic-regression analyses, the odds ratios (with 95% CIs) for fatal stroke were 0.58 (0.43 to 0.78; P<0.001) per z value of 25(OH)D and 0.62 (0.47 to 0.81; P<0.001) per z value of 1,25(OH)2D. After adjustment for several possible confounders, these odds ratios remained significant for 25(OH)D at 0.67 (0.46 to 0.97; P=0.032) and for 1,25(OH)2D at 0.72 (0.52 to 0.99; P=0.047). Z values of 25(OH)D and 1,25(OH)2D were also reduced in the 274 patients who had a history of previous cerebrovascular disease events at baseline. CONCLUSIONS: Low levels of 25(OH)D and 1,25(OH)2D are independently predictive for fatal strokes, suggesting that vitamin D supplementation is a promising approach in the prevention of strokes.
Stefan Pilz; Harald Dobnig; Joachim E Fischer; Britta Wellnitz; Ursula Seelhorst; Bernhard O Boehm; Winfried März
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-07-17
Journal Detail:
Title:  Stroke; a journal of cerebral circulation     Volume:  39     ISSN:  1524-4628     ISO Abbreviation:  Stroke     Publication Date:  2008 Sep 
Date Detail:
Created Date:  2008-08-26     Completed Date:  2008-09-25     Revised Date:  2009-02-20    
Medline Journal Info:
Nlm Unique ID:  0235266     Medline TA:  Stroke     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2611-3     Citation Subset:  IM    
Synlab Center of Laboratory Diagnostics, Heidelberg, PO Box 10470, D-69037 Heidelberg, Germany.
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MeSH Terms
Cerebral Arteries / metabolism,  physiopathology
Cohort Studies
Coronary Angiography
Coronary Artery Disease / blood,  epidemiology*,  physiopathology
Dietary Supplements / standards
Middle Aged
Multivariate Analysis
Prospective Studies
Regression Analysis
Stroke / blood,  mortality*,  physiopathology
Vitamin D / blood*,  pharmacology,  therapeutic use
Vitamin D Deficiency / blood,  epidemiology*,  physiopathology
Reg. No./Substance:
1406-16-2/Vitamin D
Comment In:
Stroke. 2009 Feb;40(2):e36; author reply e37-8   [PMID:  19095982 ]
Stroke. 2009 Feb;40(2):e35; author reply e37-8   [PMID:  19095981 ]

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