| Low vitamin D levels correlate with the proinflammatory state in type 1 diabetic subjects with and without microvascular complications. | |
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MedLine Citation:
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PMID: 21350098 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Epidemiologic studies link vitamin D deficiency to onset of type 1 diabetes mellitus (T1DM). T1DM exhibits increased inflammation, which is pronounced with microvascular complications (T1DM-MV). However, there are a paucity of data on vitamin D in T1DM-MV in relation to biomarkers of inflammation, and this formed the aim of the study. Healthy control subjects (n = 36), patients with T1DM (n = 24), and patients with T1DM-MV (n =26) were recruited. Serum vitamin D levels, monocyte toll-like receptor (TLR) 2 and TLR4 expression and nuclear factor-κB (NFκB) activity were assessed. Patients with T1DM and T1DM-MV were significantly vitamin D deficient compared with control subjects (P < .01). There was a significant negative correlation between vitamin D levels and high-sensitivity C-reactive protein, NFκB activity, and TLR4 expression (P < .05). Preincubation with vitamin D significantly decreased lipopolysaccharide-activated TLR4 expression and cytokine levels in monocytes (P < .05). Low vitamin D levels may contribute to increased inflammation in T1DM. Future studies will elucidate the immunomodulatory effects of vitamin D in decreasing vascular risk in this population. |
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Authors:
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Sridevi Devaraj; Jung-Mi Yun; Catherine R Duncan-Staley; Ishwarlal Jialal |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
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Title: American journal of clinical pathology Volume: 135 ISSN: 1943-7722 ISO Abbreviation: Am. J. Clin. Pathol. Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-02-25 Completed Date: 2011-04-12 Revised Date: 2011-11-02 |
Medline Journal Info:
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Nlm Unique ID: 0370470 Medline TA: Am J Clin Pathol Country: United States |
Other Details:
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Languages: eng Pagination: 429-33 Citation Subset: AIM; IM |
Affiliation:
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Laboratory for Atherosclerosis and Metabolic Research, UC Davis Medical Center, Sacramento, CA 95817, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult C-Reactive Protein / metabolism Diabetes Mellitus, Type 1 / complications, metabolism*, pathology Diabetic Angiopathies / complications, metabolism*, pathology Female Humans Inflammation / complications, metabolism*, pathology Male Microvessels / pathology Monocytes / metabolism, pathology Protein-Serine-Threonine Kinases / metabolism Toll-Like Receptor 2 / metabolism Toll-Like Receptor 4 / metabolism Vitamin D Deficiency / complications, metabolism*, pathology |
| Grant Support | |
ID/Acronym/Agency:
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DK69801/DK/NIDDK NIH HHS; K24AT00596/AT/NCCAM NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/TLR2 protein, human; 0/TLR4 protein, human; 0/Toll-Like Receptor 2; 0/Toll-Like Receptor 4; 9007-41-4/C-Reactive Protein; EC 2.7.11.1/Protein-Serine-Threonine Kinases; EC 2.7.11.25/NF-kappa B kinase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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