Document Detail


Low vitamin D levels correlate with the proinflammatory state in type 1 diabetic subjects with and without microvascular complications.
MedLine Citation:
PMID:  21350098     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Epidemiologic studies link vitamin D deficiency to onset of type 1 diabetes mellitus (T1DM). T1DM exhibits increased inflammation, which is pronounced with microvascular complications (T1DM-MV). However, there are a paucity of data on vitamin D in T1DM-MV in relation to biomarkers of inflammation, and this formed the aim of the study. Healthy control subjects (n = 36), patients with T1DM (n = 24), and patients with T1DM-MV (n =26) were recruited. Serum vitamin D levels, monocyte toll-like receptor (TLR) 2 and TLR4 expression and nuclear factor-κB (NFκB) activity were assessed. Patients with T1DM and T1DM-MV were significantly vitamin D deficient compared with control subjects (P < .01). There was a significant negative correlation between vitamin D levels and high-sensitivity C-reactive protein, NFκB activity, and TLR4 expression (P < .05). Preincubation with vitamin D significantly decreased lipopolysaccharide-activated TLR4 expression and cytokine levels in monocytes (P < .05). Low vitamin D levels may contribute to increased inflammation in T1DM. Future studies will elucidate the immunomodulatory effects of vitamin D in decreasing vascular risk in this population.
Authors:
Sridevi Devaraj; Jung-Mi Yun; Catherine R Duncan-Staley; Ishwarlal Jialal
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  American journal of clinical pathology     Volume:  135     ISSN:  1943-7722     ISO Abbreviation:  Am. J. Clin. Pathol.     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-02-25     Completed Date:  2011-04-12     Revised Date:  2011-11-02    
Medline Journal Info:
Nlm Unique ID:  0370470     Medline TA:  Am J Clin Pathol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  429-33     Citation Subset:  AIM; IM    
Affiliation:
Laboratory for Atherosclerosis and Metabolic Research, UC Davis Medical Center, Sacramento, CA 95817, USA.
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MeSH Terms
Descriptor/Qualifier:
Adult
C-Reactive Protein / metabolism
Diabetes Mellitus, Type 1 / complications,  metabolism*,  pathology
Diabetic Angiopathies / complications,  metabolism*,  pathology
Female
Humans
Inflammation / complications,  metabolism*,  pathology
Male
Microvessels / pathology
Monocytes / metabolism,  pathology
Protein-Serine-Threonine Kinases / metabolism
Toll-Like Receptor 2 / metabolism
Toll-Like Receptor 4 / metabolism
Vitamin D Deficiency / complications,  metabolism*,  pathology
Grant Support
ID/Acronym/Agency:
DK69801/DK/NIDDK NIH HHS; K24AT00596/AT/NCCAM NIH HHS
Chemical
Reg. No./Substance:
0/TLR2 protein, human; 0/TLR4 protein, human; 0/Toll-Like Receptor 2; 0/Toll-Like Receptor 4; 9007-41-4/C-Reactive Protein; EC 2.7.11.1/Protein-Serine-Threonine Kinases; EC 2.7.11.25/NF-kappa B kinase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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