Document Detail

Low vitamin K intakes in community-dwelling elders at an early stage of Alzheimer's disease.
MedLine Citation:
PMID:  19027415     Owner:  NLM     Status:  MEDLINE    
An increasing body of evidence points to a role for vitamin K in brain physiology through its participation in sphingolipid metabolism and biological activation of the vitamin K-dependent protein Gas6. One hypothesis is that vitamin K may also play a role in the pathogenesis of Alzheimer's disease. A recent study found that patients with early-stage Alzheimer's disease consumed less vitamin K than did cognitively intact control subjects. To learn more about the dietary intakes and food sources of vitamin K in these patients, a detailed analysis was conducted. Dietary vitamin K intakes were assessed from 5 nonconsecutive days of food records collected from 31 community-dwelling patients with early-stage Alzheimer's disease and in 31 age- and sex-matched cognitively intact control subjects. Mean vitamin K intake on a person-day basis was 63+/-90 microg/day in patients and 139+/-233 microg/day in control subjects. Vitamin K intakes were significantly less in participants with Alzheimer's disease (P<0.0001), even after adjusting for energy intakes (P=0.0003). Vegetables, fats, and fruits contributed more than 70% of total vitamin K intake in both groups. The main source of vitamin K was green vegetables, which contributed 33% and 49% to total intakes in patients and control subjects, respectively. This lower consumption of green vegetables in participants with Alzheimer's disease explained their lower vitamin K intakes overall. Despite their limitations, results are in line with the most recent research in both vitamin K and Alzheimer's disease and suggest a need to consider vitamin K in future investigations on the role of diet in Alzheimer's disease.
Nancy Presse; Bryna Shatenstein; Marie-Jeanne Kergoat; Guylaine Ferland
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of the American Dietetic Association     Volume:  108     ISSN:  0002-8223     ISO Abbreviation:  J Am Diet Assoc     Publication Date:  2008 Dec 
Date Detail:
Created Date:  2008-11-25     Completed Date:  2009-01-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7503061     Medline TA:  J Am Diet Assoc     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2095-9     Citation Subset:  AIM; IM    
Département de Nutrition, Université de Montréal, Montréal, Canada.
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MeSH Terms
Aging / physiology
Alzheimer Disease / epidemiology*,  etiology*,  metabolism
Case-Control Studies
Diet Records
Food Analysis
Nutritional Requirements
Nutritional Status*
Vegetables / chemistry
Vitamin K / administration & dosage*,  physiology
Reg. No./Substance:
12001-79-5/Vitamin K

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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