Document Detail

Low vitamin D status is associated with reduced muscle mass and impaired physical performance in frail elderly people.
MedLine Citation:
PMID:  23942175     Owner:  NLM     Status:  Publisher    
Background/Objectives:Serum 25-hydroxyvitamin D (25(OH)D) status has been associated with muscle mass, strength and physical performance in healthy elderly people. Yet, in pre-frail and frail elderly people this association has not been studied. The objective of this study was to explore the association between vitamin D intake and serum 25(OH)D status with muscle mass, strength and physical performance in a pre-frail and frail elderly population.Subjects/Methods:This cross-sectional study included 127 pre-frail and frail elderly people in The Netherlands. Whole body and appendicular lean mass (ALM) (dual energy X-ray absorptiometry), leg strength (one repetition maximum), handgrip strength and physical performance (short physical performance battery) were measured, and blood samples were collected for the assessment of serum 25(OH)D status (liquid chromatography-tandem mass spectrometry). In addition, habitual dietary intake (3-day food records) and physical activity data (accelerometers) were collected.Results:In total, 53% of the participants had a serum 25(OH)D level below 50 nmol/l. After adjustment for confounding factors, 25(OH)D status was associated with ALM (β=0.012, P=0.05) and with physical performance (β=0.020, P<0.05). Vitamin D intake was associated with physical performance (β=0.18, P<0.05) but not with ALM (P>0.05).Conclusion:In this frail elderly population, 25(OH)D status is low and suggests a modest association with reduced ALM and impaired physical performance. In addition, vitamin D intake tended to be associated with impaired physical performance. Our findings highlight the need for well-designed intervention trials to assess the impact of vitamin D supplementation on 25(OH)D status, muscle mass and physical performance in pre-frail and frail elderly people.European Journal of Clinical Nutrition advance online publication, 14 August 2013; doi:10.1038/ejcn.2013.144.
M Tieland; E M Brouwer-Brolsma; C Nienaber-Rousseau; L J C van Loon; L C P G M De Groot
Related Documents :
19373425 - A new method for total mercury and methyl mercury analysis in muscle of seawater fish.
4087375 - Carnitine derivatives in hereditary cardiomyopathic animals.
22667465 - A new and reliable animal model for optic nerve injury.
20971495 - Bisphenol a content in fish caught in two different sites of the tyrrhenian sea (italy).
10607505 - The distribution of nerve fibres immunoreactive for vasoactive intestinal peptide, calc...
9579595 - Bilateral four-headed biceps brachii muscles: the median nerve and brachial artery pass...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-8-14
Journal Detail:
Title:  European journal of clinical nutrition     Volume:  -     ISSN:  1476-5640     ISO Abbreviation:  Eur J Clin Nutr     Publication Date:  2013 Aug 
Date Detail:
Created Date:  2013-8-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8804070     Medline TA:  Eur J Clin Nutr     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
1] Top Institute Food and Nutrition, Wageningen, The Netherlands [2] Division of Human Nutrition, Wageningen University, Wageningen, The Netherlands.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  How Can We Improve Transfer of Outcomes from Randomized Clinical Trials to Clinical Practice with Di...
Next Document:  A narrative review of recent progress in understanding the relationship between tuberculosis and pro...