| Low usage rate of banked sibling cord blood units in hematopoietic stem cell transplantation for children with hematological malignancies: Implications for directed cord blood banking policies. | |
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MedLine Citation:
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PMID: 21095146 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Directed sibling cord blood banking is indicated in women delivering healthy babies who already have a sibling with a disease that is potentially treatable with an allogeneic cord blood transplant. We evaluated the effectiveness of a national directed cord blood banking program in sibling HLA-identical stem cell transplantation for hematological malignancies and the factors influencing the usage rate of the stored cord blood units. Fifty families were enrolled from which, 48 cord blood units were successfully collected and 2 collections failed due to damaged cord/placenta at delivery. Among enrolled families 4 children needed transplantation; however, only one was successfully transplanted using the collected cord blood unit containing 2×10(7) nucleated cells/kg in conjunction with a small volume of bone marrow from the same HLA-identical donor. Two children received grafts from matched unrelated donors because their sibling cord blood was HLA-haploidentical, while the fourth one received bone marrow from his HLA-identical brother, since cord blood could not be collected due to damaged cord/placenta at delivery. With a median follow-up of 6years (range, 2-12) for the 9 remaining HLA-matched cord blood units, none from the prospective recipients needed transplantation. The low utilization rate of sibling cord blood in the setting of hematopoietic stem cell transplantation for pediatric hematological malignant diseases necessitates the development of directed cord blood banking programs that limit long-term storage for banked cord blood units with low probability of usage such as non-HLA-identical or identical to patients who are in long-term complete remission. |
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Authors:
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Evgenios Goussetis; Ioulia Peristeri; Vasiliki Kitra; Andreas C Papassavas; Maria Theodosaki; Eftichia Petrakou; Antonia Spiropoulos; Anna Paisiou; Alexandra Soldatou; Catherine Stavropoulos-Giokas; Stelios Graphakos |
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Publication Detail:
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Type: Journal Article Date: 2010-11-20 |
Journal Detail:
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Title: Blood cells, molecules & diseases Volume: 46 ISSN: 1096-0961 ISO Abbreviation: Blood Cells Mol. Dis. Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-01-31 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9509932 Medline TA: Blood Cells Mol Dis Country: United States |
Other Details:
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Languages: eng Pagination: 177-81 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Elsevier Inc. All rights reserved. |
Affiliation:
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Stem Cell Transplant Unit, Aghia Sophia Children's Hospital, Thivon and Papadiamantopoulou, 11527 Athens, Greece. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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