| Low urinary sodium is associated with greater risk of myocardial infarction among treated hypertensive men. | |
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MedLine Citation:
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PMID: 7768554 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A sodium-reduced diet is frequently recommended for hypertensive individuals. To determine the relationship of sodium intake to subsequent cardiovascular disease, we assessed the experience of participants in a worksite-based cohort of hypertensive subjects. The 24-hour urinary excretion of sodium (UNaV), potassium, creatinine, and plasma renin activity was measured in 2937 mildly and moderately hypertensive subjects who were unmedicated for at least 3-4 weeks. Morbidity and mortality in these systematically treated subjects were ascertained. Men and women were stratified according to sex-specific quartiles of UNaV. Subjects in these strata were similar in race, cardiovascular status, and pretreatment and intreatment blood pressure. Subjects with lower UNaV were thinner, excreted less potassium, and had higher plasma renin activity. During an average 3.8 years of follow-up, a total of 55 myocardial infarctions occurred. Myocardial infarction and UNaV were inversely associated in the total population and in men but not in women, who sustained only nine events. In men, age- and race-adjusted myocardial infarction incidence in the lowest versus highest UNaV quartile was 11.5 versus 2.5 (relative risk, 4.3, 95% confidence interval, 1.7-10.6). No association was observed between non-cardiovascular disease mortality (n = 11) and UNaV. There was a significant linear trend in proportions of myocardial infarction by UNaV quartile, with a break point after the lowest UNaV quartile.(ABSTRACT TRUNCATED AT 250 WORDS) |
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Authors:
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M H Alderman; S Madhavan; H Cohen; J E Sealey; J H Laragh |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Hypertension Volume: 25 ISSN: 0194-911X ISO Abbreviation: Hypertension Publication Date: 1995 Jun |
Date Detail:
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Created Date: 1995-06-30 Completed Date: 1995-06-30 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 7906255 Medline TA: Hypertension Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1144-52 Citation Subset: IM |
Affiliation:
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Department of Epidemiology and Social Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Cerebrovascular Disorders / etiology Cohort Studies Female Humans Hypertension / complications*, urine Male Middle Aged Multivariate Analysis Myocardial Infarction / etiology* Prospective Studies Risk Sodium / urine* Sodium, Dietary / administration & dosage |
| Grant Support | |
ID/Acronym/Agency:
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HL-18323/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Sodium, Dietary; 7440-23-5/Sodium |
| Comments/Corrections | |
Comment In:
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Hypertension. 1995 Jun;25(6):1153-4
[PMID:
7768555
]
Hypertension. 1996 Jan;27(1):156; author reply 156-7 [PMID: 8591881 ] Hypertension. 1996 Jan;27(1):155; author reply 156-7 [PMID: 8591880 ] |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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