Document Detail


Low urinary dopamine excretion associated to low sodium excretion in normotensive Piaroa Amazonian ethnia compared to urban subjects.
MedLine Citation:
PMID:  7548301     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The objective of this work was to compare urinary dopamine, noradrenaline, adrenaline, sodium and potassium excretion in a group of normotensive Piaroa Amazonic ethnia who do not use salt in their regular food intake, against a group of urban normotensive citizens known to have a high salt intake in their regular meals. Twenty adult normotensive Piaroa subjects living in the Amazonas forest, 11 men and 9 women, 23-72 years old, and 33 normotensive urban citizens, 25-70 years old, 17 men and 17 women, were included in the study. After a 10 min. rest, an average of three supine systolic (SBP) and diastolic (DBP) blood pressure recordings was obtained. Piaroas subjects SBP and DBP were 111.3 +/- 2.9 mmHg and 62.7 +/- 1.9 mmHg respectively; urban subjects SBP and DBP were 111.8 +/- 2.2 mmHg and 70.3 +/- 1.6 mmHg respectively. Supine heart rate was lower in Piaroas (58.0 +/- 1.8 beats/min) than in urban subjects (76.5 +/- 1.9 beats/min), p < 0.05. Sodium urinary excretion was much lower in Piaroas (12.6 +/- 5.2 mmol/24 h) when compared to urban subjects (210.7 +/- 24.5 mmol/24 h), p < 0.01. No difference was found in daily urinary potassium excretion between Piaroas and urban subjects (50.4 +/- 7.2 mmol/24 h vs 45.1 +/- 7.4 mmol/24 h). Urinary dopamine excretion was lower in Piaroas (314.7 +/- 40.1 micrograms/24 h) in comparison to urban subjects (800.4 +/- 59.2 micrograms/24 h), p < 0.05. Daily urinary noradrenaline and adrenaline excretion were 67.9% and 85.4% respectively lower in Piaroas than in urban subjects. In conclusion, lower amounts of sodium daily intake are associated to lower kidney dopamine production in Piaroas as compared to urban subjects. Apparently indigenous tribes might require less kidney dopamine synthesis to excrete the very small amounts of salt they consume in their regular food intake. The opposite was found in urban subjects; more kidney dopamine synthesis would be required for larger amounts of urinary sodium excretion. In this population, essential hypertension has been associated to a failure of the natriuretic mechanism triggered by dopamine onkidney tubules.
Authors:
E Romero-Vecchione; J Vásquez; G Lema; H Guerrero; F Rosa; M Bermúdez
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Investigación clínica     Volume:  36     ISSN:  0535-5133     ISO Abbreviation:  Invest Clin     Publication Date:  1995 Jun 
Date Detail:
Created Date:  1995-10-24     Completed Date:  1995-10-24     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0421531     Medline TA:  Invest Clin     Country:  VENEZUELA    
Other Details:
Languages:  eng     Pagination:  61-71     Citation Subset:  IM    
Affiliation:
Laboratorio de Estudios Cardiovasculares, Escuela de Medicina José María Vargas, Facultad de Medicina, Universidad Central de Venezuela, San José, Caracas.
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MeSH Terms
Descriptor/Qualifier:
Adult
Dopamine / urine*
Epinephrine / urine
Female
Humans
Indians, South American*
Male
Middle Aged
Norepinephrine / urine
Potassium / urine
Sodium / urine*
Urban Population*
Venezuela
Chemical
Reg. No./Substance:
51-41-2/Norepinephrine; 51-43-4/Epinephrine; 7440-09-7/Potassium; 7440-23-5/Sodium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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