Document Detail

Low umbilical artery vascular flow resistance and fetal outcome.
MedLine Citation:
PMID:  15059155     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: An abnormally high [above mean + 2 standard deviations (SD)] umbilical artery (UA) pulsatility index (PI) indicates impaired fetal outcome, whereas the impact of an "abnormally" low (below mean -2 SD) PI is unknown. METHODS: Perinatal outcome was compared between cases with a UA PI less than mean -2 SD (group A: high-risk cases selected from a database, n = 330; group B: unselected cases, n = 39) and unselected controls (group C) with a PI within mean +/- 2 SD (n = 863) at Doppler velocimetry. Groups B and C were retrieved from a population-based sample. The unpaired t-test, Mann-Whitney U-test, chi(2)-test and Fisher's exact probability test were used for statistical comparisons with a two-tailed p < 0.05 being significant. RESULTS: No significant differences were found between group A vs. group C and group B vs. group C regarding perinatal mortality, Apgar scores at 1, 5 or 10 min, or arterial or venous cord blood pH. Postterm pregnancy in group A carried no additional risk. For obvious reasons, operative delivery and neonatal intensive care were more common in group A than in group C, but no such differences were found between groups B and C. The mean birthweight was 3.7% higher in group B than in group C (p = 0.049). CONCLUSIONS: Deeming a UA PI below the lower reference limit as "abnormally" low is a statistical definition that was not reflected by a biological imperfection. Instead, a low UA PI promoted fetal growth.
Per Olofsson; Hanna Olofsson; Johan Molin; Karel Marsál
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta obstetricia et gynecologica Scandinavica     Volume:  83     ISSN:  0001-6349     ISO Abbreviation:  Acta Obstet Gynecol Scand     Publication Date:  2004 May 
Date Detail:
Created Date:  2004-04-02     Completed Date:  2004-05-13     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370343     Medline TA:  Acta Obstet Gynecol Scand     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  440-2     Citation Subset:  IM    
Department of Obstetrics and Gynecology, Malmö University Hospital, S-205 02 Malmö, Sweden.
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MeSH Terms
Blood Flow Velocity
Case-Control Studies
Fetus / blood supply*
Pregnancy Outcome*
Pulsatile Flow
Sweden / epidemiology
Umbilical Arteries / physiology*
Vascular Resistance

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