| Low umbilical artery vascular flow resistance and fetal outcome. | |
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MedLine Citation:
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PMID: 15059155 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: An abnormally high [above mean + 2 standard deviations (SD)] umbilical artery (UA) pulsatility index (PI) indicates impaired fetal outcome, whereas the impact of an "abnormally" low (below mean -2 SD) PI is unknown. METHODS: Perinatal outcome was compared between cases with a UA PI less than mean -2 SD (group A: high-risk cases selected from a database, n = 330; group B: unselected cases, n = 39) and unselected controls (group C) with a PI within mean +/- 2 SD (n = 863) at Doppler velocimetry. Groups B and C were retrieved from a population-based sample. The unpaired t-test, Mann-Whitney U-test, chi(2)-test and Fisher's exact probability test were used for statistical comparisons with a two-tailed p < 0.05 being significant. RESULTS: No significant differences were found between group A vs. group C and group B vs. group C regarding perinatal mortality, Apgar scores at 1, 5 or 10 min, or arterial or venous cord blood pH. Postterm pregnancy in group A carried no additional risk. For obvious reasons, operative delivery and neonatal intensive care were more common in group A than in group C, but no such differences were found between groups B and C. The mean birthweight was 3.7% higher in group B than in group C (p = 0.049). CONCLUSIONS: Deeming a UA PI below the lower reference limit as "abnormally" low is a statistical definition that was not reflected by a biological imperfection. Instead, a low UA PI promoted fetal growth. |
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Authors:
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Per Olofsson; Hanna Olofsson; Johan Molin; Karel Marsál |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Acta obstetricia et gynecologica Scandinavica Volume: 83 ISSN: 0001-6349 ISO Abbreviation: Acta Obstet Gynecol Scand Publication Date: 2004 May |
Date Detail:
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Created Date: 2004-04-02 Completed Date: 2004-05-13 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0370343 Medline TA: Acta Obstet Gynecol Scand Country: Denmark |
Other Details:
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Languages: eng Pagination: 440-2 Citation Subset: IM |
Affiliation:
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Department of Obstetrics and Gynecology, Malmö University Hospital, S-205 02 Malmö, Sweden. per.olofsson@obst.mas.lu.se |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Blood Flow Velocity Case-Control Studies Female Fetus / blood supply* Humans Pregnancy Pregnancy Outcome* Pulsatile Flow Sweden / epidemiology Umbilical Arteries / physiology* Vascular Resistance |
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