| Low troponin-I levels on admission are associated with worse prognosis in patients with fulminant myocarditis. | |
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MedLine Citation:
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PMID: 19715884 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: The clinical outcomes of patients with fulminant acute myocarditis (FAM) range from death to complete recovery. We sought to identify clinical, biological, and echocardiographic characteristics of prognostic value for this population. METHODS AND RESULTS: We prospectively included 185 patients with the diagnosis of acute myocarditis who were admitted to our institution between 2000 and 2007, selecting 15 who displayed FAM, namely, severe congestive heart failure or cardiogenic shock, requiring inotropic and/or mechanical circulatory support. Their mean age was 27.9 +/- 12.4 years (range, 12-52) and mean left ventricular ejection fraction (LVEF) was 22 +/- 8.4% (range, 10-35). Seven subjects had poor outcomes, defined as death (n = 4), urgent transplantation (x = 2), or persistent left ventricular dysfunction (n = 3). The other 6 individuals experienced complete recovery of ventricular function. Troponin-I values below 1 ng/mL on admission were significantly associated with greater in-hospital (P = .05) and mid-term poor outcomes (P = .001). Additionally, patients with poor outcomes showed significantly lower LVEF (17.6 +/- 6.2% vs 28.8 +/- 6.9%; P = .006). CONCLUSION: Among patients with FAM, normal or minimal elevation of troponin-I and low LVEF on admission were associated with worse in-hospital and mid-term prognosis. |
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Authors:
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X Freixa; A Sionis; A Castel; E Guasch; P Loma-Osorio; D Arzamendi; E Roig; F Perez-Villa |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Transplantation proceedings Volume: 41 ISSN: 1873-2623 ISO Abbreviation: Transplant. Proc. Publication Date: 2009 Jul-Aug |
Date Detail:
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Created Date: 2009-08-31 Completed Date: 2010-01-11 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0243532 Medline TA: Transplant Proc Country: United States |
Other Details:
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Languages: eng Pagination: 2234-6 Citation Subset: IM |
Affiliation:
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Cardiology Department, Thorax Institute, Hospital Clinic of Barcelona, Barcelona, Spain. freixa@clinic.ub.es |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acute Disease Adolescent Adult C-Reactive Protein / metabolism Child Female Heart Failure / blood, mortality, surgery Heart Transplantation / physiology* Humans Male Middle Aged Myocarditis / blood*, classification, surgery Prognosis Severity of Illness Index Shock, Cardiogenic / surgery Treatment Outcome Troponin I / blood* Ventricular Dysfunction, Left / blood, surgery Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Troponin I; 9007-41-4/C-Reactive Protein |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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