Document Detail

Low tidal volume ventilation in healthy dogs.
MedLine Citation:
PMID:  22702442     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To determine if low tidal volume (V(T) ) ventilation is associated with the development of respiratory acidosis and changes in lung function in healthy dogs.
DESIGN: Randomized prospective experimental cross-over study.
SETTING: Pulmonary function laboratory at a university teaching hospital.
ANIMALS: Five healthy Beagle dogs.
INTERVENTIONS: Dogs were anesthetized and randomly mechanically ventilated with V(T) of 6, 8, 10, 12, and 15 mL/kg while maintaining a constant minute volume.
MEASUREMENTS AND MAIN RESULTS: Arterial blood gases and pulmonary mechanics were collected after 15 minutes of equilibration at each V(T). Repeated measures ANOVA was used to determine the effect of V(T) with a P-value of <0.05 considered significant, and a Pearson product moment was used to determine correlation between V(T) and pH and PaCO(2). V(T) had a significant effect on PaCO(2) (P < 0.001) and on pH (P < 0.001) with lower V(T) being associated with higher PaCO(2) and lower pH. There was a strong correlation between V(T) and PaCO(2) (r = -0.87) and V(T) and pH (r = 0.83). Increased airway pressures and pulmonary compliance were associated with increasing V(T).
CONCLUSIONS: There is a predictable decrease in the pH, decrease in airway pressure, decrease in compliance, and increase in the PaCO(2) associated with lower V(T). Low V(T) ventilation is well tolerated in healthy dogs; the role of low V(T) ventilation in dogs with acute lung injury/acute respiratory distress syndrome as well as the influence of positive end expiratory pressure requires further evaluation.
Trisha Oura; Elizabeth A Rozanski; Gareth Buckley; Daniela Bedenice
Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001)     Volume:  22     ISSN:  1476-4431     ISO Abbreviation:  J Vet Emerg Crit Care (San Antonio)     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-06-18     Completed Date:  2012-10-23     Revised Date:  2012-12-24    
Medline Journal Info:
Nlm Unique ID:  101152804     Medline TA:  J Vet Emerg Crit Care (San Antonio)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  368-71     Citation Subset:  IM    
Copyright Information:
© Veterinary Emergency and Critical Care Society 2012.
Department of Clinical Sciences, Tufts Cummings School of Veterinary Medicine, North Grafton, MA 01536, USA.
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MeSH Terms
Analysis of Variance
Blood Gas Analysis / veterinary
Carbon Dioxide / blood
Cross-Over Studies
Dogs / physiology*
Hydrogen-Ion Concentration
Lung Compliance
Respiration, Artificial / methods,  veterinary*
Tidal Volume / physiology*
Reg. No./Substance:
124-38-9/Carbon Dioxide
Comment In:
J Vet Emerg Crit Care (San Antonio). 2012 Oct;22(5):526; author reply 526-7   [PMID:  23110566 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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