| Low susceptibility of trophozoites of virulent Entamoeba histolytica to cellular and antibody-dependent cellular cytotoxicity by guinea-pig effector cells. | |
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MedLine Citation:
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PMID: 2902704 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Cytotoxic potentialities of lymphocytes and macrophages were determined against trophozoites of virulent and avirulent sublines of Entamoeba histolytica in vitro. Guinea-pigs were immunized with antigens of both sublines to obtain stimulated effector cells and antiamoebic antibodies. Trophozoites of an avirulent/attenuated subline of E. histolytica (NIH200) were significantly more susceptible to killing by lymphocytes and macrophages through cellular and antibody-dependent cellular cytotoxic mechanisms. The resistance of virulent trophozoites to killing was attributed to their higher phagocytic ability and virulence characteristics. Electron microscopic studies of the interactions showed that contact between the effector cells and the trophozoites was essential for the cytolytic event which resulted in disintegration of the trophozoites. Antigens of trophozoites of the virulence subline of E. histolytica (NIH200 V) were effective in inducing cytotoxicity against both virulent and avirulent trophozoites: however, the reverse was not true. |
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Authors:
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A Saxena; V K Vinayak |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Transactions of the Royal Society of Tropical Medicine and Hygiene Volume: 81 ISSN: 0035-9203 ISO Abbreviation: Trans. R. Soc. Trop. Med. Hyg. Publication Date: 1987 |
Date Detail:
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Created Date: 1988-11-23 Completed Date: 1988-11-23 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7506129 Medline TA: Trans R Soc Trop Med Hyg Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 933-7 Citation Subset: IM |
Affiliation:
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Department of Experimental Medicine, Post-Graduate Institute of Medical Education and Research, Chandigarh, India. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antibodies, Protozoan / immunology* Antibody-Dependent Cell Cytotoxicity* Cell Line Entamoeba histolytica / immunology* Guinea Pigs Lymphocytes / immunology* Macrophages / immunology* |
| Chemical | |
Reg. No./Substance:
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0/Antibodies, Protozoan |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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