Document Detail

Low susceptibility to the induction of experimental autoimmune encephalomyelitis in a substrain of the otherwise susceptible Lewis rat.
MedLine Citation:
PMID:  6180908     Owner:  NLM     Status:  MEDLINE    
A substrain of the Lewis rat, Lew/Mol, differing from ordinary Lewis rats in that it is hardly susceptible to the induction of experimental autoimmune encephalomyelitis (EAE) is described. The Lew/Mol rats did not mount a host-vs.-graft response towards cells from an EAE-susceptible substrain of Lewis rats (Lew/Mai) and vice versa. This argues against the possibility that the origin of Lew/Mol rats involves accidental cross-breeding with other rat strains. Thus the EAE-resistance in Lew/Mol rats in interpreted as being due to a mutation(s) in a gene(s) regulating the susceptibility to EAE. Specific pathogen-free Lew/Mol rats were more resistant to EAE induction than Lew/Mol rats bred under conventional conditions, emphasizing the importance of environmental factors. Neither cyclophosphamide treatment nor increased age resulted in marked susceptibility in the Lew/Mol rats, although aging apparently had some effect, as a few animals did show neurological signs. Approximately half of (Lew/Mol x Lew/Mai)F1 hybrids developed EAE with neurological signs. In this respect, Lew/Mol rats differ from another recently described EAE-resistant substrain of the Lewis rat (LeR).
B Källén; L Lögdberg
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European journal of immunology     Volume:  12     ISSN:  0014-2980     ISO Abbreviation:  Eur. J. Immunol.     Publication Date:  1982 Jul 
Date Detail:
Created Date:  1982-12-02     Completed Date:  1982-12-02     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1273201     Medline TA:  Eur J Immunol     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  596-9     Citation Subset:  IM    
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MeSH Terms
Crosses, Genetic
Cyclophosphamide / pharmacology
Disease Susceptibility
Encephalomyelitis, Autoimmune, Experimental / diagnosis,  etiology*,  physiopathology
Myelin Basic Proteins
Rats, Inbred BN
Rats, Inbred F344
Rats, Inbred Lew / genetics*
Rats, Inbred Strains / genetics*
Reg. No./Substance:
0/Myelin Basic Proteins; 50-18-0/Cyclophosphamide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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