| Low susceptibility to the induction of experimental autoimmune encephalomyelitis in a substrain of the otherwise susceptible Lewis rat. | |
MedLine Citation:
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PMID: 6180908 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A substrain of the Lewis rat, Lew/Mol, differing from ordinary Lewis rats in that it is hardly susceptible to the induction of experimental autoimmune encephalomyelitis (EAE) is described. The Lew/Mol rats did not mount a host-vs.-graft response towards cells from an EAE-susceptible substrain of Lewis rats (Lew/Mai) and vice versa. This argues against the possibility that the origin of Lew/Mol rats involves accidental cross-breeding with other rat strains. Thus the EAE-resistance in Lew/Mol rats in interpreted as being due to a mutation(s) in a gene(s) regulating the susceptibility to EAE. Specific pathogen-free Lew/Mol rats were more resistant to EAE induction than Lew/Mol rats bred under conventional conditions, emphasizing the importance of environmental factors. Neither cyclophosphamide treatment nor increased age resulted in marked susceptibility in the Lew/Mol rats, although aging apparently had some effect, as a few animals did show neurological signs. Approximately half of (Lew/Mol x Lew/Mai)F1 hybrids developed EAE with neurological signs. In this respect, Lew/Mol rats differ from another recently described EAE-resistant substrain of the Lewis rat (LeR). |
Authors:
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B Källén; L Lögdberg |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: European journal of immunology Volume: 12 ISSN: 0014-2980 ISO Abbreviation: Eur. J. Immunol. Publication Date: 1982 Jul |
Date Detail:
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Created Date: 1982-12-02 Completed Date: 1982-12-02 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 1273201 Medline TA: Eur J Immunol Country: GERMANY, WEST |
Other Details:
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Languages: eng Pagination: 596-9 Citation Subset: IM |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aging Animals Crosses, Genetic Cyclophosphamide / pharmacology Disease Susceptibility Encephalomyelitis, Autoimmune, Experimental / diagnosis, etiology*, physiopathology Environment Female Male Myelin Basic Proteins Rats Rats, Inbred BN Rats, Inbred F344 Rats, Inbred Lew / genetics* Rats, Inbred Strains / genetics* |
| Chemical | |
Reg. No./Substance:
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0/Myelin Basic Proteins; 50-18-0/Cyclophosphamide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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