Document Detail


Low-speed treadmill running exercise improves memory function after transient middle cerebral artery occlusion in rats.
MedLine Citation:
PMID:  23266325     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Physical exercise may enhance the recovery of impaired memory function in stroke rats. However the appropriate conditions of exercise and the mechanisms underlying these beneficial effects are not yet known. Therefore, the purpose of this study was to investigate the effect exercise intensity on memory function after cerebral infarction in rats. The animals were subjected to middle cerebral artery occlusion (MCAO) for 90min to induce stroke and were randomly assigned to four groups; Low-Ex, High-Ex, Non-Ex and Sham. On the fourth day after surgery, rats in the Low-Ex and High-Ex groups were forced to exercise using a treadmill for 30min every day for four weeks. Memory functions were examined during the last 5 days of the experiment (27-32 days after MCAO) by three types of tests: an object recognition test, an object location test and a passive avoidance test. After the final memory test, the infarct volume, number of neurons and microtubule-associated protein 2 (MAP2) immunoreactivity in the hippocampus were analyzed by histochemistry. Memory functions in the Low-Ex group were improved in all tests. In the High-Ex group, only the passive avoidance test improved, but not the object recognition or object location tests. Both the Low-Ex and High-Ex groups had reduced infarct volumes. Although the number of neurons in the hippocampal dentate gyrus of the Low-Ex and High-Ex groups was increased, the number for the Low-Ex group increased more than that for the High-Ex group. Moreover hippocampal MAP2 immunoreactivity in the High-Ex group was reduced compared to that in the Low-Ex group. These data suggest that the effects of exercise on memory impairment after cerebral infarction depend on exercise intensity.
Authors:
Haruka Shimada; Michiru Hamakawa; Akimasa Ishida; Keigo Tamakoshi; Hiroki Nakashima; Kazuto Ishida
Related Documents :
23300795 - Effects of blood flow restricted low-intensity concentric or eccentric training on musc...
3694095 - Detection and measurement of the p-wave and t-wave during exercise testing using combin...
24130005 - Cardiovascular effects of 1 year of alagebrium and endurance exercise training in healt...
16878715 - Reproducibility of automated pulse wave velocity measurement during exercise. running h...
17946755 - Posture classification via wearable strain sensors for neurological rehabilitation.
10831175 - Exercise-induced microalbuminuria in patients with active acromegaly: acute effects of ...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-12-20
Journal Detail:
Title:  Behavioural brain research     Volume:  -     ISSN:  1872-7549     ISO Abbreviation:  Behav. Brain Res.     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-12-25     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8004872     Medline TA:  Behav Brain Res     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012. Published by Elsevier B.V.
Affiliation:
Department of Physical Therapy, Nagoya University Graduate School of Medicine, Nagoya, Aichi 461-8673, Japan; Kariya Toyota General Hospital, Kariya, Aichi 448-8505, Japan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  How to make a good egg!: The need for remodeling of oocyte Ca(2+) signaling to mediate the egg-to-em...
Next Document:  Serotonin transporter gene moderates associations between mood, memory and hippocampal volume.