Document Detail

Low serum vitamin B-12 and folate concentrations and low thiamin and riboflavin intakes are inversely associated with greater adiposity in mexican american children.
MedLine Citation:
PMID:  25411037     Owner:  NLM     Status:  In-Data-Review    
BACKGROUND: Micronutrient status may be a contributing factor to the development of childhood obesity in many industrializing countries passing the nutritional transition. The few studies investigating associations between serum concentrations of vitamin B and intake of B vitamins with adiposity, however, have reported inconsistent findings.
OBJECTIVE: The aim of the study was to examine associations between serum vitamin B-12 and folate concentrations and intakes of B vitamins with body fat by using data on 1131 Mexican American children 8-15 y of age included in NHANES 2001-2004.
METHODS: Children's body mass index (BMI), trunk fat mass (TrFM), and total body fat mass (TBFM) were used as body adiposity (BA) measures. Serum concentrations of folate and vitamin B-12 were measured in blood samples collected from children. Intake of B vitamins was collected according to 24-h dietary recall. Associations of BA with serum concentrations of vitamin B-12 and folate and intake of B vitamins were determined by using linear and multinomial regression models.
RESULTS: Serum concentrations of vitamin B-12 and folate were inversely associated with BMI (β: -2.68, P < 0.01; β = -1.33, P < 0.01), TrFM (β:-3.32, P < 0.01; β: -0.14, P < 0.05), and TBFM (β:-1.93, P < 0.01; β: -3.19; P < 0.01). Higher serum concentrations of vitamin B-12 were associated with a reduced risk of obesity (OR: 0.48; 95% CI: 0.31, 0.77; P < 0.001). Thiamin and riboflavin intakes were inversely associated with BMI (β:-1.35, P < 0.05; β: -1.11, P < 0.05) and TrFM (β:-1.26, P < 0.05; β: -1.37, P < 0.05).
CONCLUSION: Similar inverse associations between BA and status of both vitamin B-12 and folate and intake of thiamin and riboflavin suggest that these micronutrients may play a role in adipogenesis and risk of childhood obesity.
Inong R Gunanti; Geoffrey C Marks; Abdullah Al-Mamun; Kurt Z Long
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Publication Detail:
Type:  Journal Article     Date:  2014-10-08
Journal Detail:
Title:  The Journal of nutrition     Volume:  144     ISSN:  1541-6100     ISO Abbreviation:  J. Nutr.     Publication Date:  2014 Dec 
Date Detail:
Created Date:  2014-11-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0404243     Medline TA:  J Nutr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2027-33     Citation Subset:  IM    
Copyright Information:
© 2014 American Society for Nutrition.
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