Document Detail

Low serum folate but normal homocysteine levels in patients with atherosclerotic vascular disease and matched healthy controls.
MedLine Citation:
PMID:  10869899     Owner:  NLM     Status:  MEDLINE    
Mild hyperhomocysteinemia has been considered a cardiovascular risk factor. However, recent prospective studies have not demonstrated that hyperhomocysteinemia or the underlying genetic defect on methylentetrahydrofolate reductase is associated with a higher risk of coronary or peripheral artery disease. We compared serum homocysteine, folate, and vitamin B(12) levels of patients with coronary and peripheral vascular disease with those of age- and sex-matched healthy individuals. Subjects taking multivitamins, with diabetes mellitus, or serum creatinine levels over 1.5 mg/dL were excluded from the study. Homocysteine was measured by fluorimetric high-performance liquid chromatography. Serum folate and vitamin B(12) levels were measured by an ion-capture method. We studied 32 patients with peripheral vascular disease (10 female), aged 69.6 +/- 11 y, 24 age- and sex-matched control subjects, 52 patients with coronary artery disease (7 female), aged 59.5 +/- 10.4 y, and 42 age- and sex-matched control subjects. Serum homocysteine levels were 11.7 +/- 7.4 and 9.3 +/- 4.5 micromol/L in vascular patients and in the control counterparts, respectively (not significant). The levels for coronary patients and the control counterparts were 9.0 +/- 3.9 and 8.6 +/- 3.6 micromol/L, respectively (not significant). Folate levels were 4.48 +/- 2.42 and 7.14 +/- 4.04 ng/mL in vascular patients and control subjects, respectively (P < 0.02); the levels in coronary patients and control counterparts were 5.15 +/- 1.9 and 6.59 +/- 2.49 ng/mL, respectively (P < 0.01). No differences in vitamin B(12) or tocopherol levels were observed between patients and control subjects. There were no differences in homocysteine levels, but lower serum folate levels were observed when comparing patients with atherosclerotic vascular disease and healthy control subjects.
D Bunout; M Petermann; S Hirsch; P de la Maza; M Suazo; G Barrera; R Kauffman
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Nutrition (Burbank, Los Angeles County, Calif.)     Volume:  16     ISSN:  0899-9007     ISO Abbreviation:  Nutrition     Publication Date:  2000 Jun 
Date Detail:
Created Date:  2000-08-03     Completed Date:  2000-08-03     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8802712     Medline TA:  Nutrition     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  434-8     Citation Subset:  IM    
INTA and Faculty of Medicine, University of Chile, Santiago, Chile.
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MeSH Terms
Arteriosclerosis / blood*,  complications
Cholesterol / blood
Chromatography, High Pressure Liquid
Coronary Disease / blood
Folic Acid / blood
Folic Acid Deficiency / complications*
Homocysteine / blood*
Lipoproteins, HDL / blood
Middle Aged
Risk Factors
Triglycerides / blood
Vitamin B 12 / blood
Vitamin E / blood
Reg. No./Substance:
0/Lipoproteins, HDL; 0/Triglycerides; 1406-18-4/Vitamin E; 454-28-4/Homocysteine; 57-88-5/Cholesterol; 59-30-3/Folic Acid; 68-19-9/Vitamin B 12

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