| Low serum endothelial cell-selective adhesion molecule predicts increase in albuminuria in type 2 diabetes patients. | |
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MedLine Citation:
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PMID: 23292509 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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PURPOSE: The newly discovered endothelial cell-selective adhesion molecule (ESAM) stabilizes the interendothelial tight junction; it circulates in serum as a soluble fraction. In experimental diabetes, reduced ESAM expression in the kidney is associated with albuminuria. We investigated, for the first time, serum ESAM as a predictor of progression of kidney disease in type 2 diabetes (T2D). METHODS: T2D non-nephrotic patients with glomerular filtration rate (GFR) > 30 ml/min were included. History, medication and laboratory evaluation were assessed at inclusion and the end of study; ESAM was determined at baseline. RESULTS: Eighty-eight patients-mean age 63 ± 10.84 years, 49 (55.68 %) males-were prospectively followed up for 20 months. Baseline GFR was 76.37 ± 29.56 ml/min, and urinary albumin/creatinine ratio (UACR) 21.63(7.08-94.52) mg/g; ESAM was 12.85(6.13-19.83) ng/ml. Difference (Δ) in UACR between end of study and baseline was inversely related to serum albumin (r = -0.27, p = 0.017) and ESAM (r = -0.21, p = 0.047); ΔGFR correlated to glycated hemoglobin (r = 0.22, p = 0.05). In multiple regression, introducing variables susceptible to influence progression of kidney disease, ΔUACR was significantly related to log ESAM (p = 0.005) and ΔGFR to glycated hemoglobin (p = 0.016). CONCLUSION: Serum ESAM is a predictor of worsening of albuminuria in T2D patients without advanced kidney disease. |
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Authors:
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Ina Maria Kacso; Cosmina Ioana Bondor; Gabriel Kacso |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2013-1-5 |
Journal Detail:
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Title: International urology and nephrology Volume: - ISSN: 1573-2584 ISO Abbreviation: Int Urol Nephrol Publication Date: 2013 Jan |
Date Detail:
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Created Date: 2013-1-7 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0262521 Medline TA: Int Urol Nephrol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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University of Medicine and Pharmacy "Iuliu Hatieganu" Cluj Napoca, Dornei 47 street, 400171, Cluj Napoca, Romania. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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