Document Detail


Low serum endothelial cell-selective adhesion molecule predicts increase in albuminuria in type 2 diabetes patients.
MedLine Citation:
PMID:  23292509     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
PURPOSE: The newly discovered endothelial cell-selective adhesion molecule (ESAM) stabilizes the interendothelial tight junction; it circulates in serum as a soluble fraction. In experimental diabetes, reduced ESAM expression in the kidney is associated with albuminuria. We investigated, for the first time, serum ESAM as a predictor of progression of kidney disease in type 2 diabetes (T2D). METHODS: T2D non-nephrotic patients with glomerular filtration rate (GFR) > 30 ml/min were included. History, medication and laboratory evaluation were assessed at inclusion and the end of study; ESAM was determined at baseline. RESULTS: Eighty-eight patients-mean age 63 ± 10.84 years, 49 (55.68 %) males-were prospectively followed up for 20 months. Baseline GFR was 76.37 ± 29.56 ml/min, and urinary albumin/creatinine ratio (UACR) 21.63(7.08-94.52) mg/g; ESAM was 12.85(6.13-19.83) ng/ml. Difference (Δ) in UACR between end of study and baseline was inversely related to serum albumin (r = -0.27, p = 0.017) and ESAM (r = -0.21, p = 0.047); ΔGFR correlated to glycated hemoglobin (r = 0.22, p = 0.05). In multiple regression, introducing variables susceptible to influence progression of kidney disease, ΔUACR was significantly related to log ESAM (p = 0.005) and ΔGFR to glycated hemoglobin (p = 0.016). CONCLUSION: Serum ESAM is a predictor of worsening of albuminuria in T2D patients without advanced kidney disease.
Authors:
Ina Maria Kacso; Cosmina Ioana Bondor; Gabriel Kacso
Related Documents :
22624859 - Cannabidiol inhibits angiogenesis by multiple mechanisms.
18362839 - Tissue adhesives and the pancreas: biocompatibility and adhesive properties of 6 prepar...
10772099 - Effect of carboxymethylcellulose and a hyaluronate-carboxymethylcellulose membrane on h...
23275299 - Role of endothelial-mesenchymal transition in idiopathic portal hypertension.
24721189 - Endothelial microparticles as conveyors of information in atherosclerotic disease.
22581629 - Phage-derived fully human antibody scfv fragment directed against human vascular endoth...
9775229 - Do corneal endothelial dystrophies represent ocular neurocristopathies? a discussion on...
25388209 - Cellular and regional specific changes in multidrug efflux transporter expression durin...
1720159 - Multiple roles of leu-8/mel-14 in leukocyte adhesion and function.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-5
Journal Detail:
Title:  International urology and nephrology     Volume:  -     ISSN:  1573-2584     ISO Abbreviation:  Int Urol Nephrol     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-7     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0262521     Medline TA:  Int Urol Nephrol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
University of Medicine and Pharmacy "Iuliu Hatieganu" Cluj Napoca, Dornei 47 street, 400171, Cluj Napoca, Romania.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Haematuria and acute kidney injury in elderly patients admitted to hospital with supratherapeutic wa...
Next Document:  Primary squamous cell carcinoma of seminal vesicle: an extremely rare case report with literature re...