| Low serum cortisol predicts early death after acute myocardial infarction. | |
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MedLine Citation:
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PMID: 20081532 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To determine whether low serum cortisol concentrations are associated with adverse prognosis in patients with acute myocardial infarction. Low serum cortisol concentrations have been associated with adverse prognosis in critical illness of diverse etiology. DESIGN: Nested case-control study. SETTING: Prospective cohort study of consecutive patients admitted with acute myocardial infarction to nine Scottish hospitals. PATIENTS: A total of 100 patients who survived 30 days (controls) and 100 patients who died within 30 days (cases). MEASUREMENTS AND MAIN RESULTS: Admission cortisol concentrations were lower in patients who died than those who survived (median, 1189 nmol/L vs. 1355 nmol/L; p < .001). A cortisol concentration in the bottom quartile (<1136 nmol/L) was a strong predictor of death within 30 days and remained so after adjustment for age and cardiac troponin concentration (adjusted odds ratio, 8.78; 95% confidence interval, 3.09-24.96; p < .001). CONCLUSIONS: Patients who mount a lesser cortisol stress response to acute myocardial infarction have a poorer early prognosis. |
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Authors:
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Rebecca M Reynolds; Brian R Walker; Sally Haw; David E Newby; Daniel F Mackay; Stuart M Cobbe; Alastair C H Pell; Colin Fischbacher; Stuart Pringle; David Murdoch; Frank Dunn; Keith Oldroyd; Paul Macintyre; Brian O'Rourke; Jill P Pell |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Critical care medicine Volume: 38 ISSN: 1530-0293 ISO Abbreviation: Crit. Care Med. Publication Date: 2010 Mar |
Date Detail:
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Created Date: 2010-02-19 Completed Date: 2010-03-15 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0355501 Medline TA: Crit Care Med Country: United States |
Other Details:
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Languages: eng Pagination: 973-5 Citation Subset: AIM; IM |
Affiliation:
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Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aged, 80 and over Case-Control Studies Cohort Studies Female Follow-Up Studies Hospital Mortality Humans Hydrocortisone / blood* Intensive Care Units Male Middle Aged Myocardial Infarction / blood*, mortality* Prognosis Prospective Studies Scotland Survival Analysis Troponin / blood |
| Grant Support | |
ID/Acronym/Agency:
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//British Heart Foundation |
| Chemical | |
Reg. No./Substance:
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0/Troponin; 50-23-7/Hydrocortisone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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