Document Detail

Low serum cholic acid concentration of Duchenne muscular dystrophy.
MedLine Citation:
PMID:  6660426     Owner:  NLM     Status:  MEDLINE    
Serum bile acids of 15 patients with Duchenne muscular dystrophy (DMD) were analyzed by gas-liquid chromatography. The serum cholic acid values were unusually low (0.16 +/- 0.13 microM), even less than 0.01 microgram/ml in 4, compared with controls (1.47 +/- 0.17 microM). HDL-cholesterol was within normal limits. The low concentration of serum cholic acid may be causative of abnormal calcium mobilization in DMD. The intracellular calcium mobilization seems to be affected by serum cholic acid as indicated by the enhanced rate of loss of intracellular calcium from the muscle exposed to cholic acid, which acts as a calcium-ionophore and reversibly forms soluble complexes with calcium ions.
K Tanaka; K Takeshita; I Suganuma; S Kasagi
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Brain & development     Volume:  5     ISSN:  0387-7604     ISO Abbreviation:  Brain Dev.     Publication Date:  1983  
Date Detail:
Created Date:  1984-02-24     Completed Date:  1984-02-24     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7909235     Medline TA:  Brain Dev     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  511-3     Citation Subset:  IM    
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MeSH Terms
Calcium / metabolism
Cell Membrane Permeability
Cholic Acid
Cholic Acids / blood*,  metabolism
Liver / metabolism
Muscular Dystrophies / blood*,  metabolism
Reg. No./Substance:
0/Cholic Acids; 7440-70-2/Calcium; 81-25-4/Cholic Acid

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