Document Detail

Low serum carotenoids are associated with a decline in walking speed in older women.
MedLine Citation:
PMID:  19262947     Owner:  NLM     Status:  MEDLINE    
BACKGROUND AND OBJECTIVES: Walking speed is an important measure of physical performance that is predictive of disability and mortality. The relationship of dietary factors to changes in physical performance has not been well characterized in older adults. The aim was to determine whether total serum carotenoid concentrations, a marker for fruit and vegetable intake, and serum selenium are related to changes in walking speed in older women.
SUBJECTS AND METHODS: The relationship between total serum carotenoids and selenium measured at baseline, 12, and 24 months follow-up and walking speed assessed at baseline and every six months for 36 months was examined in 687 moderately to severely disabled women, 65 years or older, living in the community.
RESULTS: Mean total serum carotenoids were associated with mean walking speed over three years of follow-up (P = 0.0003) and rate of change of walking speed (P = 0.007) in multivariate linear regression models adjusting for age, body mass index, and chronic diseases. Mean serum selenium was associated with mean walking speed over three years of follow-up (P = 0.0003) but not with the rate of change of walking speed (P = 0.26).
CONCLUSIONS: These findings suggest that a higher fruit and vegetable intake, as indicated by higher total serum carotenoid concentrations, may be protective against a decline in walking speed in older women.
N Alipanah; R Varadhan; K Sun; L Ferrucci; L P Fried; R D Semba
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural    
Journal Detail:
Title:  The journal of nutrition, health & aging     Volume:  13     ISSN:  1279-7707     ISO Abbreviation:  J Nutr Health Aging     Publication Date:  2009 Mar 
Date Detail:
Created Date:  2009-03-05     Completed Date:  2009-11-03     Revised Date:  2013-06-24    
Medline Journal Info:
Nlm Unique ID:  100893366     Medline TA:  J Nutr Health Aging     Country:  France    
Other Details:
Languages:  eng     Pagination:  170-5     Citation Subset:  IM    
Johns Hopkins Medical Institutions, Baltimore, MD, USA.
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MeSH Terms
Activities of Daily Living
Aged, 80 and over
Biological Markers / blood
Carotenoids / blood*
Chromatography, High Pressure Liquid
Disabled Persons / statistics & numerical data
Follow-Up Studies
Geriatric Assessment / methods,  statistics & numerical data
Mobility Limitation*
Motor Activity
Selenium / blood*
Severity of Illness Index
Walking / physiology*,  statistics & numerical data*
Women's Health
Grant Support
AG11703-01A1/AG/NIA NIH HHS; N01-AG12112/AG/NIA NIH HHS; R01 AG027012/AG/NIA NIH HHS; R01 AG027012/AG/NIA NIH HHS; R37 AG019905/AG/NIA NIH HHS; RR00722/RR/NCRR NIH HHS; Z01 AG000015-50/AG/NIA NIH HHS
Reg. No./Substance:
0/Biological Markers; 36-88-4/Carotenoids; 7782-49-2/Selenium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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