Document Detail


Low serum adiponectin is independently associated with both the metabolic syndrome and angiographically determined coronary atherosclerosis.
MedLine Citation:
PMID:  17550784     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: We aimed at investigating serum adiponectin in patients with the metabolic syndrome (MetS), in patients with angiographically diagnosed coronary artery disease (CAD), and in patients who had both, the MetS and CAD. METHODS: We enrolled 687 consecutive patients undergoing coronary angiography for the evaluation of CAD. RESULTS: From our patients, 178 had neither the MetS (Adult Treatment Panel III definition) nor significant CAD (MetS-/CAD-), 91 had the MetS, but not significant CAD (MetS+/CAD-), 251 did not have the MetS but had significant CAD (MetS-/CAD+), and 167 had both, the MetS and significant CAD (MetS+/CAD+). Serum adiponectin was highest (12.1+/-8.3 microg/ml) in MetS-/CAD- subjects. It was significantly lower in MetS+/CAD- (9.5+/-7.3 microg/ml; p=0.001) and in MetS-/CAD+ patients (9.2+/-5.3 microg/ml; p<0.001) and lowest in MetS+/CAD+ patients (6.7+/-3.8 microg/ml) in whom it was significantly lower than in MetS-/CAD-, MetS+/CAD-, and MetS-/CAD+ patients (p<0.001 for all comparisons). In analysis of covariance the MetS and significant CAD proved associated with serum adiponectin in a mutually independent manner. CONCLUSIONS: Low serum adiponectin is independently associated with both the MetS and coronary atherosclerosis.
Authors:
Christoph H Saely; Lorenz Risch; Guenter Hoefle; Philipp Rein; Axel Muendlein; Thomas Marte; Stefan Aczel; Peter Langer; Heinz Drexel
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-05-10
Journal Detail:
Title:  Clinica chimica acta; international journal of clinical chemistry     Volume:  383     ISSN:  0009-8981     ISO Abbreviation:  Clin. Chim. Acta     Publication Date:  2007 Aug 
Date Detail:
Created Date:  2007-07-09     Completed Date:  2007-10-09     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  1302422     Medline TA:  Clin Chim Acta     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  97-102     Citation Subset:  IM    
Affiliation:
Vorarlberg Institute for Vascular Investigation and Treatment (VIVIT), Carinagasse 47, A-6800 Feldkirch, Austria.
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MeSH Terms
Descriptor/Qualifier:
Adiponectin / blood*
Aged
Analysis of Variance
Case-Control Studies
Coronary Angiography
Coronary Artery Disease / blood*,  complications
Down-Regulation
Female
Humans
Male
Metabolic Syndrome X / blood*,  complications,  diagnosis
Middle Aged
Chemical
Reg. No./Substance:
0/Adiponectin

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