| Low serum adiponectin is independently associated with both the metabolic syndrome and angiographically determined coronary atherosclerosis. | |
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MedLine Citation:
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PMID: 17550784 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: We aimed at investigating serum adiponectin in patients with the metabolic syndrome (MetS), in patients with angiographically diagnosed coronary artery disease (CAD), and in patients who had both, the MetS and CAD. METHODS: We enrolled 687 consecutive patients undergoing coronary angiography for the evaluation of CAD. RESULTS: From our patients, 178 had neither the MetS (Adult Treatment Panel III definition) nor significant CAD (MetS-/CAD-), 91 had the MetS, but not significant CAD (MetS+/CAD-), 251 did not have the MetS but had significant CAD (MetS-/CAD+), and 167 had both, the MetS and significant CAD (MetS+/CAD+). Serum adiponectin was highest (12.1+/-8.3 microg/ml) in MetS-/CAD- subjects. It was significantly lower in MetS+/CAD- (9.5+/-7.3 microg/ml; p=0.001) and in MetS-/CAD+ patients (9.2+/-5.3 microg/ml; p<0.001) and lowest in MetS+/CAD+ patients (6.7+/-3.8 microg/ml) in whom it was significantly lower than in MetS-/CAD-, MetS+/CAD-, and MetS-/CAD+ patients (p<0.001 for all comparisons). In analysis of covariance the MetS and significant CAD proved associated with serum adiponectin in a mutually independent manner. CONCLUSIONS: Low serum adiponectin is independently associated with both the MetS and coronary atherosclerosis. |
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Authors:
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Christoph H Saely; Lorenz Risch; Guenter Hoefle; Philipp Rein; Axel Muendlein; Thomas Marte; Stefan Aczel; Peter Langer; Heinz Drexel |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2007-05-10 |
Journal Detail:
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Title: Clinica chimica acta; international journal of clinical chemistry Volume: 383 ISSN: 0009-8981 ISO Abbreviation: Clin. Chim. Acta Publication Date: 2007 Aug |
Date Detail:
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Created Date: 2007-07-09 Completed Date: 2007-10-09 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 1302422 Medline TA: Clin Chim Acta Country: Netherlands |
Other Details:
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Languages: eng Pagination: 97-102 Citation Subset: IM |
Affiliation:
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Vorarlberg Institute for Vascular Investigation and Treatment (VIVIT), Carinagasse 47, A-6800 Feldkirch, Austria. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adiponectin
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blood* Aged Analysis of Variance Case-Control Studies Coronary Angiography Coronary Artery Disease / blood*, complications Down-Regulation Female Humans Male Metabolic Syndrome X / blood*, complications, diagnosis Middle Aged |
| Chemical | |
Reg. No./Substance:
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0/Adiponectin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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