| Low serum C3, leukopenia, and thrombocytopenia: unusual features of henoch-schonlein purpura. | |
| | |
MedLine Citation:
|
PMID: 10541946 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Henoch-Schonlein purpura (HSP) affects predominantly the skin, joints, gastrointestinal tract and kidney. Although the pathogenesis is probably of immune origin and complement activation is thought to play a role, laboratory findings including the serum level of the complement components are usually normal. We present a patient with a severe form of HSP nephritis who had unusual laboratory findings of a low level of C3, mild leukopenia and thrombocytopenia. These findings may further support the importance of complement activation in the pathogenesis of HSP. |
| | |
Authors:
|
I Krause; B Z Garty; M Davidovits; R Cleper; H Tamary; E Rosenmann; B Eisenstein |
Related Documents
:
|
10807586 - C5b-9 membrane attack complex mediates endothelial cell apoptosis in experimental glome... 355576 - Host defenses in the aged: evaluation of components of the inflammatory and immune resp... 3583326 - The effect of lactoferrin on complement mediated modulation of immune complex size. 383536 - Comparison of in vivo and in vitro capability of complement fixation by pemphigus antib... 18968436 - Detection of trichinosis using tsm immunosensor. 6307866 - Chronic liver disease: the detection and characterization of circulating immune complexes. |
Publication Detail:
|
Type: Case Reports; Journal Article; Review |
Journal Detail:
|
Title: European journal of pediatrics Volume: 158 ISSN: 0340-6199 ISO Abbreviation: Eur. J. Pediatr. Publication Date: 1999 Nov |
Date Detail:
|
Created Date: 1999-12-02 Completed Date: 1999-12-02 Revised Date: 2005-11-17 |
Medline Journal Info:
|
Nlm Unique ID: 7603873 Medline TA: Eur J Pediatr Country: GERMANY |
Other Details:
|
Languages: eng Pagination: 906-9 Citation Subset: IM |
Affiliation:
|
Nephrology Clinic and Dialysis Unit, Schneider Children's Medical Center of Israel, Sackler School of Medicine, Tel-Aviv University, Petah-Tiqva, Israel. ikrause@post.tau.ac.il |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Biopsy, Needle Child Complement C3c / analysis* Disease Progression Glomerulonephritis, Membranoproliferative / etiology*, pathology, therapy Humans Kidney Failure, Chronic / surgery, therapy Kidney Transplantation Leukopenia / etiology* Male Purpura, Schoenlein-Henoch / complications, diagnosis* Renal Dialysis Thrombocytopenia / etiology* |
| Chemical | |
Reg. No./Substance:
|
80295-44-9/Complement C3c |
| Comments/Corrections | |
Comment In:
|
Eur J Pediatr. 2001 Jun;160(6):397-8
[PMID:
11421425
]
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Sacral dysgenesis associated with terminal deletion of chromosome 7q: a report of two families.
Next Document: Phototherapy for neonatal hyperbilirubinemia affects cytokine production by peripheral blood mononuc...