Document Detail


Low risk of relapse after achieving undetectable HCG levels in women with partial molar pregnancy.
MedLine Citation:
PMID:  16880311     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: We evaluated the risk of gestational trophoblastic neoplasia (GTN) for women with partial molar pregnancy whose human chorionic gonadotropin (hCG) levels fall spontaneously to undetectable levels using a sensitive hCG assay. METHODS: We analyzed data from the New England Trophoblastic Disease Center to estimate the risk of GTN among 284 women with partial molar pregnancy and at least 6 months of gonadotropin follow-up. RESULTS: None of the 238 women with complete gonadotropin follow-up and a spontaneous decline in serum hCG levels to undetectable levels subsequently developed GTN (95% confidence interval 0-1.6%). CONCLUSION: If these results are replicated at other institutions with longstanding experience managing partial molar pregnancies, it may be reasonable to abbreviate clinical follow-up for women with partial molar pregnancy whose serum hCG levels spontaneously decline to an undetectable level.
Authors:
Adam J Wolfberg; Whitfield B Growdon; Colleen M Feltmate; Donald P Goldstein; David R Genest; Manuel E Chinchilla; Ross S Berkowitz; Ellice S Lieberman
Publication Detail:
Type:  Evaluation Studies; Journal Article    
Journal Detail:
Title:  Obstetrics and gynecology     Volume:  108     ISSN:  0029-7844     ISO Abbreviation:  Obstet Gynecol     Publication Date:  2006 Aug 
Date Detail:
Created Date:  2006-08-01     Completed Date:  2006-09-07     Revised Date:  2009-10-26    
Medline Journal Info:
Nlm Unique ID:  0401101     Medline TA:  Obstet Gynecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  393-6     Citation Subset:  AIM; IM    
Affiliation:
Department of Obstetrics, Gynecology, and Reproductive Biology, Division of Gynecologic Oncology, Brigham and Women's Hospital, Boston, Massachusetts, USA. adam.wolfberg@childrens.harvard.edu
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MeSH Terms
Descriptor/Qualifier:
Adult
Chorionic Gonadotropin / blood*
Female
Humans
Hydatidiform Mole / blood*,  epidemiology,  etiology
Incidence
Massachusetts / epidemiology
Medical Records
Neoplasm Recurrence, Local / blood*,  epidemiology,  etiology
Predictive Value of Tests
Pregnancy
Registries
Retrospective Studies
Tumor Markers, Biological / blood*
Uterine Neoplasms / blood*,  epidemiology,  etiology
Chemical
Reg. No./Substance:
0/Chorionic Gonadotropin; 0/Tumor Markers, Biological

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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