| Low risk of relapse after achieving undetectable HCG levels in women with partial molar pregnancy. | |
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MedLine Citation:
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PMID: 16880311 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: We evaluated the risk of gestational trophoblastic neoplasia (GTN) for women with partial molar pregnancy whose human chorionic gonadotropin (hCG) levels fall spontaneously to undetectable levels using a sensitive hCG assay. METHODS: We analyzed data from the New England Trophoblastic Disease Center to estimate the risk of GTN among 284 women with partial molar pregnancy and at least 6 months of gonadotropin follow-up. RESULTS: None of the 238 women with complete gonadotropin follow-up and a spontaneous decline in serum hCG levels to undetectable levels subsequently developed GTN (95% confidence interval 0-1.6%). CONCLUSION: If these results are replicated at other institutions with longstanding experience managing partial molar pregnancies, it may be reasonable to abbreviate clinical follow-up for women with partial molar pregnancy whose serum hCG levels spontaneously decline to an undetectable level. |
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Authors:
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Adam J Wolfberg; Whitfield B Growdon; Colleen M Feltmate; Donald P Goldstein; David R Genest; Manuel E Chinchilla; Ross S Berkowitz; Ellice S Lieberman |
Publication Detail:
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Type: Evaluation Studies; Journal Article |
Journal Detail:
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Title: Obstetrics and gynecology Volume: 108 ISSN: 0029-7844 ISO Abbreviation: Obstet Gynecol Publication Date: 2006 Aug |
Date Detail:
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Created Date: 2006-08-01 Completed Date: 2006-09-07 Revised Date: 2009-10-26 |
Medline Journal Info:
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Nlm Unique ID: 0401101 Medline TA: Obstet Gynecol Country: United States |
Other Details:
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Languages: eng Pagination: 393-6 Citation Subset: AIM; IM |
Affiliation:
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Department of Obstetrics, Gynecology, and Reproductive Biology, Division of Gynecologic Oncology, Brigham and Women's Hospital, Boston, Massachusetts, USA. adam.wolfberg@childrens.harvard.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Chorionic Gonadotropin / blood* Female Humans Hydatidiform Mole / blood*, epidemiology, etiology Incidence Massachusetts / epidemiology Medical Records Neoplasm Recurrence, Local / blood*, epidemiology, etiology Predictive Value of Tests Pregnancy Registries Retrospective Studies Tumor Markers, Biological / blood* Uterine Neoplasms / blood*, epidemiology, etiology |
| Chemical | |
Reg. No./Substance:
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0/Chorionic Gonadotropin; 0/Tumor Markers, Biological |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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