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Low revision rate after total hip arthroplasty in patients with pediatric hip diseases.
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PMID:  23043269     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: The results of primary total hip arthroplasties (THAs) after pediatric hip diseases such as developmental dysplasia of the hip (DDH), slipped capital femoral epiphysis (SCFE), or Perthes' disease have been reported to be inferior to the results after primary osteoarthritis of the hip (OA).
MATERIALS AND METHODS: We compared the survival of primary THAs performed during the period 1995-2009 due to previous DDH, SCFE, Perthes' disease, or primary OA, using merged individual-based data from the Danish, Norwegian, and Swedish arthroplasty registers, called the Nordic Arthroplasty Register Association (NARA). Cox multiple regression, with adjustment for age, sex, and type of fixation of the prosthesis was used to calculate the survival of the prostheses and the relative revision risks.
RESULTS: 370,630 primary THAs were reported to these national registers for 1995-2009. Of these, 14,403 THAs (3.9%) were operated due to pediatric hip diseases (3.1% for Denmark, 8.8% for Norway, and 1.9% for Sweden) and 288,435 THAs (77.8%) were operated due to OA. Unadjusted 10-year Kaplan-Meier survival of THAs after pediatric hip diseases (94.7% survival) was inferior to that after OA (96.6% survival). Consequently, an increased risk of revision for hips with a previous pediatric hip disease was seen (risk ratio (RR) 1.4, 95% CI: 1.3-1.5). However, after adjustment for differences in sex and age of the patients, and in fixation of the prostheses, no difference in survival was found (93.6% after pediatric hip diseases and 93.8% after OA) (RR 1.0, CI: 1.0-1.1). Nevertheless, during the first 6 postoperative months more revisions were reported for THAs secondary to pediatric hip diseases (RR 1.2, CI: 1.0-1.5), mainly due to there being more revisions for dislocations (RR 1.8, CI: 1.4-2.3). Comparison between the different diagnosis groups showed that the overall risk of revision after DDH was higher than after OA (RR 1.1, CI: 1.0-1.2), whereas the combined group Perthes' disease/SCFE did not have a significantly different risk of revision to that of OA (RR 0.9, CI: 0.7-1.0), but had a lower risk than after DDH (RR 0.8, CI: 0.7-1.0).
INTERPRETATION: After adjustment for differences in age, sex, and type of fixation of the prosthesis, no difference in risk of revision was found for primary THAs performed due to pediatric hip diseases and those performed due to primary OA.
Authors:
Lars B Engesæter; Ingvild Ø Engesæter; Anne Marie Fenstad; Leif I Havelin; Johan Kärrholm; Göran Garellick; Alma B Pedersen; Søren Overgaard
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Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2012-10-08
Journal Detail:
Title:  Acta orthopaedica     Volume:  83     ISSN:  1745-3682     ISO Abbreviation:  Acta Orthop     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-22     Completed Date:  2013-01-01     Revised Date:  2013-07-11    
Medline Journal Info:
Nlm Unique ID:  101231512     Medline TA:  Acta Orthop     Country:  England    
Other Details:
Languages:  eng     Pagination:  436-41     Citation Subset:  IM    
Affiliation:
The Norwegian Arthroplasty Register, Department of Orthopaedic Surgery, Haukeland University Hospital, Bergen, Norway. lars.engesaeter@helse-bergen.no
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aged, 80 and over
Arthroplasty, Replacement, Hip*
Female
Hip Dislocation, Congenital / surgery*
Hip Joint*
Humans
Legg-Calve-Perthes Disease / surgery*
Male
Middle Aged
Osteoarthritis, Hip / surgery*
Registries
Reoperation
Slipped Capital Femoral Epiphyses / surgery*
Treatment Outcome
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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Journal Information
Journal ID (nlm-ta): Acta Orthop
Journal ID (iso-abbrev): Acta Orthop
Journal ID (publisher-id): ORT
ISSN: 1745-3674
ISSN: 1745-3682
Publisher: Informa Healthcare
Article Information
Download PDF
Copyright: © Nordic Orthopaedic Federation
open-access:
Received Day: 06 Month: 3 Year: 2012
Accepted Day: 25 Month: 7 Year: 2012
Print publication date: Month: 10 Year: 2012
Electronic publication date: Day: 22 Month: 10 Year: 2012
Volume: 83 Issue: 5
First Page: 436 Last Page: 441
PubMed Id: 23043269
ID: 3488168
DOI: 10.3109/17453674.2012.736171
Publisher Id: ORT_A_736171_O

Low revision rate after total hip arthroplasty in patients with pediatric hip diseases : Evaluation of 14,403 THAs due to DDH, SCFE, or Perthes’ disease and 288,435 THAs due to primary osteoarthritis in the Danish, Norwegian, and Swedish Hip Arthroplasty Registers (NARA)
Lars B Engesæter12
Ingvild Ø Engesæter12
Anne Marie Fenstad1
Leif I Havelin12
Johan Kärrholm3
Göran Garellick3
Alma B Pedersen45
Søren Overgaard46
1The Norwegian Arthroplasty Register, Department of Orthopaedic Surgery, Haukeland University Hospital, Bergen
2Department of Surgical Sciences, University of Bergen, Norway
3The Swedish Hip Arthroplasty Register, Department of Orthopaedics, Institute of Surgical Sciences, Sahlgrenska University Hospital, University of Gothenburg, Mölndal, Sweden
4The Danish Hip Arthroplasty Register, Center for Clinical Databases, Department of Clinical Epidemiology, Aarhus University Hospital
5Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus
6Department of Orthopaedic Surgery and Traumatology and Clinical Institute, Odense University Hospital, Odense, Denmark.
Correspondence: Correspondence: lars.engesaeter@helse-bergen.no

Total hip arthroplasties (THAs) after pediatric hip disease have often been reported to have inferior results as compared to THA resulting from primary osteoarthritis of the hip (OA) (Dudkiewicz et al. 2002, Sanchez-Sotelo et al. 2002). This may be explained by morphological deformities in the proximal femur or in the acetabulum, due to the disease or previous surgery, causing technical difficulties in performing the joint replacement (Sugano et al. 1998, Chougle et al. 2006). In addition, THAs in hips after pediatric hip diseases have often been combined with predictors of inferior outcome such as young age and inferior uncemented prostheses (Sugano et al. 1998, Furnes et al. 2001). However, the survival of THAs after developmental dysplasia of the hip (DDH) reported to the Norwegian Arthroplasty Register was not found to be inferior to that of THAs after OA, if adjustments for age and for type of implant were performed (Engesaeter et al. 2008). Also, in the Danish Arthroplasty Register the long-term implant survival for patients with childhood hip diseases were encouraging, although an increased risk of revision because of dislocation in the first 6 postoperative months for patients with acetabular dysplasia was found (Thillemann et al. 2008).

We now report the results of primary THA after pediatric hip diseases (DDH, slipped capital femoral epiphysis (SCFE), and Perthes’ disease), and compare them with the results of THAs due to OA, using data from the national hip arthroplasty registers in Denmark, Norway, and Sweden.


Patients and methods

This study is based on the cooperation in the Nordic Arthroplasty Register Association (NARA). Today, this is a collaboration between the national arthroplasty registers in Denmark, Finland, Norway, and Sweden. When this study was started, data from Finland were not available and only THAs from the Denmark, Norway, and Sweden were included. De-identification of the patients, including deletion of the national civil registration numbers, was performed in each national registry. The anonymous data were then merged into a common database (Havelin et al. 2009). This database contains the following data: country, age, sex, operated side, diagnosis, date of primary THA, hospital code, type of fixation of the prosthesis, type of bone cement, date of death (if applicable), and cause and date of eventual revision. For this study, primary THAs performed due to DDH, SCFE, Perthes’ disease, or OA for the period 1995–2009 were selected. In Denmark and Sweden, Perthes’ disease and SCFE were reported separately, while in Norway these 2 diagnoses were reported together.

Statistics

Survival analyses were performed using the Kaplan-Meier method and Cox regression. A Cox multiple regression model was used to study relative revision risks (failure-rate ratios) for the 4 groups of diagnoses, with adjustments for the possible influences of age (< 30, 30–39, 40–49, 50–60, 61–70, 71–80, > 80 years), sex, and the type of fixation of the implant (uncemented, cemented (both stem and cup), hybrid, or reverse hybrid (cemented cup)). Failure (revision) of the implant was defined as surgical exchange or extraction of the entire prosthesis, or any of its parts. Estimates from Cox analyses with the 4 groups of diagnoses were used to construct adjusted survival curves. 95% confidence intervals (CIs) were calculated. For revisions, the surgeon had recorded one or more reasons for failure, but in combination with infection, infection was considered to be the primary cause of revision. Aseptic loosening was otherwise counted as the principal cause of revision when given in combination with other causes. Potential overestimation of incidence of revision due to the effect of competing risks (i.e. death) was assessed by the cumulative incidence function (Gillam et al. 2010). The proportion of deaths was 7.3% for those with pediatric hip disease and 18.3% for those with OA during the follow-up, but imposed a negligible influence on the estimated risks for revisions. The extent of bilateral THAs was about 20% for patients with OA and those with pediatric hip disease, and had minimal effect on the survival estimates. Since the survival curves indicated non-proportionality, we also performed separate analyses for the first 6 months postoperatively (Figure 4) and later. The statistics package SPSS version 19.0 was used for the analyses.


Results
Epidemiology

In the period 1995–2009, 370,630 primary THAs were reported to the arthroplasty registers of Denmark, Norway, and Sweden. 14,403 THAs (3.9%) were performed due to pediatric hip disease and 288,435 THAs (77.8%) were performed due to primary OA (Table 1). Sweden contributed with 50%, Denmark with 25%, and Norway with 25% of the reported primary arthroplasties. Females constituted 66% of those with pediatric hip disease and 60% of those with OA (p < 0.001). Mean age of those operated due to pediatric hip disorders was 55 years (SD 13), and it was 69 years (SD 10) for patients with OA (p < 0.001) (Table 1).

3.3% of all primary THAs were performed due to previous DDH (12,068 THAs), but there were large differences in the 3 Nordic countries: 7.5% in Norway, 2.1% in Denmark, and 1.8% in Sweden (Table 1). SCFE and Perthes’ disease as a group were reported to be responsible for 0.6% of primary THAs (2,335 THAs), varying from 1.3% in Norway and 1.0% in Denmark to 0.1% in Sweden. In Denmark, Perthes’ disease was responsible for 0.6% of primary THAs and SCFE 0.4%, while in Sweden the numbers were 0.1% and 0.02%, respectively (Table 1).

The mean follow-up was calculated using the reverse Kaplan-Meier method. For the patients with OA, the median follow-up was 5.9 years and for those with pediatric hip disease it was 6.4 years (6.4 years for those with DDH, 7.4 years for those with SCFE, and 6.8 years for those with Perthes’ disease). The mean follow-up was therefore relatively short in all groups.

Uncemented THAs and reversed hybrids were used more commonly in patients with a pediatric hip disorder than in patients who were operated due to primary OA, while cemented THAs were less common (p < 0.001) (Figure 1).

Survival

Without any adjustment, and with any reason for revision as endpoint, the 10-year survival of THAs was 94.7% after pediatric hip disease as one group and 96.6% after OA. The overall risk of revision for THAs after previous childhood hip diseases was 1.4 times higher (CI: 1.3–1.5) than after OA (Figure 2). The corresponding risk of aseptic loosening was 1.3 times higher (CI: 1.2–1.4), for dislocation it was 1.2 times higher (CI 1.1–1.5), and for infection the risk ratio for revision was 0.8 times (CI: 0.6–1.0). However, after adjustments in the Cox model for age, sex, and type of fixation of the prosthesis and with any reason for revision as endpoint in the analyses, the 10-year survival of THAs was 93.6% after pediatric hip disease and 93.8% after OA. No statistically significant difference was found between the overall risk of revision for THAs after pediatric hip disease and that after OA (RR 1.04, CI: 1.0–1.1) (Figure 3 and Table 2). Similar results were found with aseptic loosening as endpoint (RR 1.0, CI: 0.9–1.1), with dislocation as endpoint (RR 1.1, CI: 0.9–1.3), and with infection as endpoint in the analyses (RR 0.9, CI: 0.7–1.1) (Table 2).

The first 6 months postoperatively

Restricting the analyses to revisions within 6 months postoperatively using any reason for revision as endpoint and adjusting for differences in age, sex, and type of fixation, a higher risk of revision was found for those operated for pediatric hip disease than for those operated for OA (RR 1.2, CI 1.0–1.5) (Table 3 and Figure 4). More than 6 months postoperatively, however, no differences in revision risk were detected with any reason for revision as endpoint (RR 1.0, CI: 0.9–1.1). This increased risk of early revision was mainly due to increased risk of revision due to dislocation (RR 1.8, CI: 1.4–2.3) (Table 3).

DDH compared to OA

A slightly higher overall risk of revision was found for DDH than for OA after adjustment (RR 1.1, CI: 1.0–1.2). The main reason for this difference was increased risk of dislocation (RR 1.2, CI: 1.0–1.4), while we found that there was no statistically significant change in the risk of revision due to aseptic loosening or due to infection (Table 4).

The first 6 months postoperatively, the overall risk of revision was higher for DDH than for OA (RR 1.3, CI: 1.1–1.6), while no difference was found after the first 6 months postoperatively (RR 1.1, CI: 0.98-1.2). A higher risk of early revision due to dislocation was found for DDH than for OA (RR 1.9, CI: 1.5–2.5), but there was no difference in the risk of revision due to aseptic loosening (RR 1.0, CI: 0.48–2.2) or due to infection (RR 0.68, CI: 0.38–1.2).

Perthes’ disease/SCFE compared to OA

The risk of revision for the combined group of patients with Perthes’ disease or SCFE (2,335 THAs) was compared with the risk for OA patients (288,435 THAs). No differences in the results were found (RR 0.85, CI: 0.72–1.0) with any reason for revision as endpoint after adjustment for sex, age, and type of fixation. Similar results were obtained with aseptic loosening as endpoint (RR 0.81, CI: 0.63–1.0), with dislocation as endpoint (RR 0.72, CI: 0.44–1.2), and with infection as endpoint in the analyses (RR 1.0, CI: 0.56–1.6).

In Denmark and Sweden, Perthes’ disease and SCFE were reported separately, and the results of THAs for Perthes’ disease (n = 748) and SCFE (n = 374) were compared separately to the results for OA reported for Denmark and Sweden (n = 222,841). With any reason as endpoint, with adjustment for sex, age, and type of fixation, and with OA patients as reference, no significant differences could be detected either for Perthes’ disease (RR 1.1, CI: 0.86–1.5) or for SCFE (RR 1.1, CI: 0.76–1.5). Similarly, no significant differences compared to OA were found for Perthes’ disease with aseptic loosening as endpoint (RR 1.2, CI: 0.88–1.8), for SCFE with aseptic loosening as endpoint (RR 1.0, CI: 0.64–1.7), for Perthes’ disease with dislocation as endpoint (RR 0.69, CI: 0.30–1.6), for SCFE with dislocation as endpoint (RR 0.81, CI: 0.30–2.2), for Perthes’ disease with infection as endpoint (RR 1.1, CI: 0.43–2.6), or for SCFE with infection as endpoint (RR 1.1, CI: 0.37–3.6).

Perthes’ disease/SCFE compared to DDH

Compared to DDH (n = 12,068), THAs in the combined group of Perthes’ disease and SCFE (n = 2,335) showed a reduced risk of revision with any reason for revision as endpoint (RR 0.82, CI: 0.67–0.99). We also found this reduced risk of revision using dislocation as endpoint (RR 0.56, CI: 0.33–0.95), but not with aseptic loosening (RR 0.84, CI: 0.63–0.1.1) or infection as endpoint (RR 1.1, CI: 0.57–2.0). All the risk ratios given were adjusted for age, sex, and type of fixation.

Perthes’ disease compared to SCFE

Finally, we made comparisons between THAs after Perthes’ disease (n = 748) and THAs after SCFE (n = 374). With any reason as endpoint in the analyses, with adjustment for sex, age, and type of fixation, and with Perthes’ disease as reference, no significant differences in the results could be detected (RR 0.98, CI: 0.64–1.5). No differences could be detected either with aseptic loosening as endpoint (RR 0.85, CI: 0.47–1.5), with dislocation as endpoint (RR 1.3, CI: 0.36–4.7), or with infection as endpoint (RR 1.2, CI: 0.28–5.2).


Discussion

We found no difference in the overall risk of revision of primary THA after pediatric hip diseases and after primary OA, when adjustment was done for differences in age, sex, and type of fixation of the implants. The survival of THAs after previous DDH was, however, inferior to that of THAs due to OA, mainly because of the increased risk of dislocation during the first 6 postoperative months. We found that the risk of revision was lower after Perthes’ disease/SCFE than after DDH.

These good overall results of THAs after pediatric hip disease are in accordance with other registry studies (Engesaeter et al. 2008, Thillemann et al. 2008, Boyle et al. 2012). An increased risk of revision in the first 6 months postoperatively was also reported from the Danish Arthroplasty Register (Thillemann et al. 2008). This increased risk of early revision due to dislocation of THAs after DDH is probably to be expected, since the insertion of a THA in DDH patients is often technically challenging, due to dysplastic acetabulum, narrow femur, shortening, and rotational deformity. The changed anatomy is sometimes caused by previous surgery. Frequently, special components are needed and procedures such as shortening of the femur and acetabular augmentation with superior bone grafting may be considered (Kobayashi et al. 2004, Chougle et al. 2005, Boyle et al. 2012).

The diagnosis DDH in our study included all severities of the disease. Since our dataset depended on the diagnoses reported to the different registers in Denmark, Norway, and Sweden, we had to use the type of data from the register with the least well-differentiated DDH diagnosis (“yes” or “no”). We could therefore only dichotomize regarding the DDH diagnosis and we were thus unable to stratify our results for THAs on the basis of the severity of DDH—for example, using the Crowe or Hartofilakidis classification systems (Yiannakopoulos et al. 2008).

There was a lower risk of revision for THAs after Perthes’ disease/SCFE than for THAs after DDH, either with any reason or with dislocation as endpoint. To the best of our knowledge, such differences have not been shown earlier. This might be explained by there being less morphological deformities in the acetabulum after Perthes’ disease/SCFE than after DDH, and therefore less technically demanding surgery—possibly with less risk of dislocation.

From an epidemiological point of view, it is remarkable that in Norway 7.5% of the primary THAs have been reported to be the result of DDH, while the corresponding figures are only 1.8% in Sweden and 2.1% in Denmark. Increased numbers of THAs due to DDH in Norway have also been reported from NARA earlier (Havelin et al. 2009). Increased annual age- and sex-standardized incidence of THA for primary hip osteoarthritis in females in Norway compared to Denmark, Finland, Iceland, and Sweden has been reported earlier (Lohmander et al. 2006). It could be speculated that undiagnosed DDH in childhood may be the reason behind some of the primary OA reported from Norway. The finding in the present study that DDH appears to be more common in Norwegian females could be a possible contributing factor to the observed increased incidence of THAs in Norwegian females (Lohmander et al. 2006).

Differences in the criteria of diagnoses reported to these 3 national registers could also be considered a possible explanation for variation in the reported incidence of the different diseases. The diagnoses in all 3 registers are based on the decision of the operating surgeon who fills in the form to the register immediately after surgery. In the Danish register, the diagnoses made by the surgeons in patients undergoing primary THA were validated with radiographs by independent observers and the diagnoses were confirmed in 84% of the patients (Pedersen et al. 2004). The DDH diagnosis in the Norwegian Arthroplasty Register was confirmed in 88% of the patients (Engesaeter et al. 2011) and in 91% of the patients for Perthes’ disease/SCFE (Lehmann et al. 2012).

Uncemented implants were used in 43% of patients with pediatric hip disease and in only 15% of those with primary OA. Similar proportions have been reported from the New Zealand Arthroplasty Register (Boyle et al. 2012). The use of uncemented fixation in younger patients is peculiar, since no scientific paper from any of the national joint registers has reported better results with uncemented implants (Clement et al. 2012). Thus, in our analyses statistical adjustments for fixation of the prosthesis were performed to permit comparisons of the results of the THAs linked to the different diagnoses.

In summary, the present study shows that after adjustment for differences in age, sex, and type of fixation of the implants, the results of THAs after pediatric hip disease as a group were not inferior to the results of THAs after primary osteoarthritis. However, the risk of revision of THAs after DDH is higher than the risk of revision of THAs after OA. For the combined group of Perthes’ disease and SCFE, the risk of revision of THAs is the same as that for THAs after OA.


This paper is the result of close team work. All the authors participated in the planning and design of the study and in interpretation of the results. The statistician AMF prepared data from each national register, included de-identification of the patients, and merged the selected information into the common dataset. The statistical analyses were performed by LBE and AMF. LBE and IØE wrote the manuscript, but all authors participated in revision of the manuscript.


References
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Figures

[Figure ID: F1]
Figure 1. 

Type of fixation of the prostheses in patients operated due to osteoarthritis of the hip (OA) (n = 288,435 THAs) and due to pediatric hip disease (n = 14,403 THAs). The patients with pediatric hip disease were younger than the OA patients



[Figure ID: F2]
Figure 2. 

Unadjusted survival curves in the Cox model (Kaplan-Meier curves) with any reason for revision as endpoint in the analysis, for THAs after pediatric hip disease and for THAs due to primary osteoarthritis. The two groups were not comparable, however, due to differences in age, sex, and type of fixation. (The numbers of hips at risk at 14 years were 5,885 for OA and 429 for pediatric hip disease).



[Figure ID: F3]
Figure 3. 

Survival curves with adjustment for age, sex, and type of fixation in the Cox model with any reason for revision as endpoint in the analysis, for THAs after pediatric hip disease and for THAs due to primary osteoarthritis. The numbers of hips at risk at 14 years were 5,885 for OA and 429 for pediatric hip disease.



[Figure ID: F4]
Figure 4. 

Survival in the first six months postoperatively with adjustment for age, sex, and type of fixation in the Cox model with any reason for revision as endpoint in the analysis, for THAs after pediatric hip disease and for THAs due primary osteoarthritis.



Tables
[TableWrap ID: T1] Table 1. 

Numbers of primary THAs and diagnoses (percentage, mean age, and percentage of females) in Denmark, Norway, Sweden, and altogether, for the period 1995–2009


Denmark
n = 94,252
Norway
n = 90,686
Sweden
n = 185,692
Total
n = 370,630
Diagnosis % Age
(years)
Female
(%)
% Age
(years)
Female
(%)
% Age
(years)
Female
(%)
% Age
(years)
Female
(%)
Primary OA 78.1 68.8 56.3 73.6 70.9 69.0 79.8 68.8 57.0 77.8 69.3 59.6
Pediatric hip dis. 3.1 51.9 58.6 8.8 57.0 68.0 1.9 53.4 65.5 3.9 55.1 65.5
 DDH 2.1 52.9 71.2 7.5 58.0 75.3 1.8 53.8 67.4 3.3 56.0 72.5
 Perthes’ 0.6 49.5 29.3 0.1 47.2 38.2 0.2 48.9 31.6
 SCFE 0.4 49.3 32.4 0.02 53.0 38.2 0.1 49.7 32.9
 SCFE/Perthes’ 1.3 51.6 27.1 0.3 51.6 27.1
Other 18.8 68.0 65.4 17.6 69.3 70.2 18.4 71.5 71.8 18.3 70.0 69.7
All 100 68.2 58.1 100 69.4 69.1 100 69.0 59.9 100 68.9 61.7

[TableWrap ID: T2] Table 2. 

Results for primary THAs after pediatric hip disease and after primary osteoarthritis. Adjusted for age, sex, and type of fixation in the Cox model, with endpoints as indicated


Endpoint in the analysis No. of
THAs
No. of
revisions
10–year
survival a
RR b 95% CI c p–value
Any reason for revision 302,838 12,067
 Pediatric hip disease 14,403 853 93.6% 1.04 0.96–1.12 0.4
 Primary osteoarthritis 288 435 11,214 93.8% 1
Aseptic loosening 302 838 5,803
 Pediatric hip disease 14,403 396 97.2% 1.00 0.89–1.11 1.0
 Primary osteoarthritis 288 435 5,407 97.0% 1
Dislocation 302 838 2,641
 Pediatric hip disease 14,403 156 98.7% 1.10 0.92–1.31 0.3
 Primary osteoarthritis 288 435 2,485 98.8% 1
Infection 302 838 1,806
 Pediatric hip disease 14,403 72 99.3% 0.86 0.67–1.10 0.2
 Primary osteoarthritis 288 435 1,734 99.3% 1

T2-N1a Cox–adjusted 10–year survival.

T2-N2b Cox relative revision risk.

T2-N3c 95% confidence interval for RR.


[TableWrap ID: T3] Table 3. 

Results for the first 6 postoperative months for primary THAs after pediatric hip disease and after primary osteoarthritis a


Endpoint in the analysis No. of
THAs
No. of
revisions
RR 95% CI p–value
Any reason for revision 302,838 2,289
 Pediatric hip diseases 14,403 141 1.24 1.03–1.50 0.02
 Primary osteoarthritis 288 435 2,148 1
Aseptic loosening 302 838 154
 Pediatric hip diseases 14,403 9 0.95 0.46–1.95 0.9
 Primary osteoarthritis 288 435 145 1
Dislocation 302 838 1,020
 Pediatric hip diseases 14,403 78 1.78 1.38–2.30 < 0.001
 Primary osteoarthritis 288 435 942 1
Infection 302 838 637
 Pediatric hip diseases 14,403 17 0.73 0.44–1.20 0.2
 Primary osteoarthritis 288 435 620 1

T3-N1a For full explanation, see Table 2.


[TableWrap ID: T4] Table 4. 

Results for primary THAs after previous DDH and after primary osteoarthritis


Endpoint in the analysis No. of
THAs
No. of
revisions
10–year
survival a
RR b 95% CI c p–value
Any reason for revision 300,503 11,922
 DDH 12,068 706 93.3% 1.09 1.00–1.18 0.04
 Primary osteoarthritis 288 435 11,214 93.8% 1
Aseptic loosening 300 503 5,803
 DDH 12,068 325 97.1% 1.05 0.93–1.18 0.5
 Primary osteoarthritis 288 435 5,407 97.0% 1
Dislocation 300 503 2,641
 DDH 12,068 138 98.7% 1.18 0.98–1.42 0.08
 Primary osteoarthritis 288 435 2,485 98.8% 1
Infection 300 503 1,806
 DDH 12,068 57 99.5% 0.85 0.65–1.12 0.3
 Primary osteoarthritis 288 435 1,734 99.3% 1

For full explanation, see Table 2.



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