| Low renin-aldosterone in "prehypertensive" young adults. | |
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MedLine Citation:
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PMID: 7037816 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PRA is suppressed in approximately 25% of patients with essential hypertension. To determine if renin suppression precedes the onset of hypertension, PRA and plasma aldosterone were measured before and after treadmill exercise in 129 young adults with relatively high, intermediate, or relatively low blood pressures sustained over 5 yr. PRA and aldosterone responses to exercise were lower (P less than 0.01) in the high blood pressure group. In contrast, plasma renin substrate was lower (P less than 0.01) in the low blood pressure group. Unrelated to blood pressure, PRA, but not aldosterone, was lower in black than in white subjects both before and after exercise. In conclusion, renin suppression precedes the onset of hypertension and may be an appropriate response to higher levels of arterial pressure. |
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Authors:
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T A Kotchen; G P Guthrie; C M Cottrill; H E McKean; J M Kotchen |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Journal of clinical endocrinology and metabolism Volume: 54 ISSN: 0021-972X ISO Abbreviation: J. Clin. Endocrinol. Metab. Publication Date: 1982 Apr |
Date Detail:
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Created Date: 1982-05-27 Completed Date: 1982-05-27 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 0375362 Medline TA: J Clin Endocrinol Metab Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 808-14 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent African Continental Ancestry Group Aldosterone / blood* Blood Pressure* Contraceptives, Oral / pharmacology Creatinine / blood European Continental Ancestry Group Female Humans Hydrocortisone / blood Male Physical Exertion* Potassium / blood Renin / blood* Sex Factors |
| Chemical | |
Reg. No./Substance:
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0/Contraceptives, Oral; 50-23-7/Hydrocortisone; 52-39-1/Aldosterone; 60-27-5/Creatinine; 7440-09-7/Potassium; EC 3.4.23.15/Renin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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