| Low relative skeletal muscle mass indicative of sarcopenia is associated with elevations in serum uric acid levels: findings from NHANES III. | |
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MedLine Citation:
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PMID: 19262948 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Sarcopenia may be related to increases in reactive oxygen species formation and inflammation, both of which are associated with elevations in serum uric acid. OBJECTIVE: To test the hypothesis that a reduced skeletal muscle mass index, indicative of sarcopenia, is related to elevations in uric acid. DESIGN: Cross-sectional analysis of nationally representative data. SETTING: Third National Health and Nutrition Examination Survey, 1988-1994. PATIENTS: 7544 men and women 40 years of age and older who had uric acid, skeletal muscle mass, and select covariate information. MEASUREMENTS: Skeletal muscle mass assessment was based on a previously published equation including height, BIA-resistance, gender, and age. Absolute skeletal muscle mass was calculated for all study population individuals and compared against the sex-specific mean for younger adults. Serum uric acid data were gathered from the NHANES laboratory file. RESULTS: A logistic regression analysis revealed that elevations in serum uric acid are significantly related to sarcopenia status. For every unit (mg/dL) increase in uric acid, the odds ratio of manifesting a skeletal muscle mass index at least one standard deviation below the reference mean was 1.12. Participants in the highest grouping (> 8 mg/dL) of serum uric acid concentration had 2.0 times the odds of manifesting sarcopenia compared to the lowest grouping (< 6 mg/dL) (p < 0.01) after adjusting for the additional covariates. LIMITATIONS: This study design was limited in its cross-sectional nature. Potential selection, measurement, and recall bias may have occurred, and methodology used to classify sarcopenia status based on skeletal muscle mass index is not validated. CONCLUSION: This observation provides support for the theory that elevations in uric acid may lead to sarcopenia, although the proposed mechanism needs further experimental support. |
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Authors:
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K M Beavers; D P Beavers; M C Serra; R G Bowden; R L Wilson |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The journal of nutrition, health & aging Volume: 13 ISSN: 1279-7707 ISO Abbreviation: J Nutr Health Aging Publication Date: 2009 Mar |
Date Detail:
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Created Date: 2009-03-05 Completed Date: 2009-11-03 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100893366 Medline TA: J Nutr Health Aging Country: France |
Other Details:
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Languages: eng Pagination: 177-82 Citation Subset: IM |
Affiliation:
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Baylor University, Center for Exercise, Nutrition, and Preventive Health Research, Department of Health, Human Performance, and Recreation, Waco, TX 76798-7313, USA. Kristen_Beavers@baylor.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Aging Cross-Sectional Studies Female Health Status Health Surveys Humans Inflammation / blood, physiopathology Interviews as Topic Male Middle Aged Muscle, Skeletal / pathology, physiopathology* Muscular Atrophy / blood*, physiopathology Nutrition Surveys Odds Ratio Reactive Oxygen Species / blood United States Uric Acid / blood* |
| Chemical | |
Reg. No./Substance:
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0/Reactive Oxygen Species; 69-93-2/Uric Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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