Document Detail


Low protein intake is associated with reduced hepatic gluconeogenic enzyme expression in rainbow trout (Oncorhynchus mykiss).
MedLine Citation:
PMID:  12888637     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Our objective was to understand the reasons behind the persistent postprandial hyperglycemia in rainbow trout (Oncorhynchus mykiss). We hypothesized that in this species, high levels of dietary protein could increase the hepatic production of glucose, irrespective of the dietary carbohydrate supply. We fed juvenile rainbow trout four diets containing graded levels of protein for 14 d. Pair-feeding was employed to keep lipid and carbohydrate intakes constant. Six hours after feeding, as postulated, activities and mRNA levels of gluconeogenic enzymes (glucose-6-phosphatase, fructose-1,6-bisphosphatase) increased with increasing dietary protein (P < 0.05). However, in fish with a very low protein intake, there was a very strong increase in plasma glucose (18 mmol/L) that was also associated with a high capacity to store excess glucose as indicated by altered pyruvate kinase activity, glucokinase activity, and hepatic glycogen and fat concentrations (P < 0.05). In conclusion, at the same level of carbohydrate intake, a low dietary protein intake was associated with an unexplained increase in glycemia, which was probably responsible for the decrease in hepatic gluconeogenic enzyme expression. The effect of dietary protein on low carbohydrate utilization in this species remains unclear.
Authors:
Séverine Kirchner; Sadasivam Kaushik; Stéphane Panserat
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of nutrition     Volume:  133     ISSN:  0022-3166     ISO Abbreviation:  J. Nutr.     Publication Date:  2003 Aug 
Date Detail:
Created Date:  2003-07-30     Completed Date:  2003-11-06     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0404243     Medline TA:  J Nutr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2561-4     Citation Subset:  IM    
Affiliation:
Laboratory of Fish Nutrition, INRA-IFREMER, 64310 St-Pée-sur-Nivelle, France.
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MeSH Terms
Descriptor/Qualifier:
Animals
Blood Glucose / analysis
Dietary Proteins / administration & dosage*
Fructose-Bisphosphatase / metabolism*
Glucokinase / metabolism
Gluconeogenesis / physiology*
Glucose / metabolism
Glucose-6-Phosphatase / metabolism*
Glycogen / metabolism
Lipid Metabolism
Liver / enzymology*
Oncorhynchus mykiss / metabolism*
Pyruvate Kinase / metabolism
Chemical
Reg. No./Substance:
0/Blood Glucose; 0/Dietary Proteins; 50-99-7/Glucose; 9005-79-2/Glycogen; EC 2.7.1.2/Glucokinase; EC 2.7.1.40/Pyruvate Kinase; EC 3.1.3.11/Fructose-Bisphosphatase; EC 3.1.3.9/Glucose-6-Phosphatase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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