Document Detail


Low protein Z levels, but not the intron F G79A polymorphism, are associated with unexplained pregnancy loss.
MedLine Citation:
PMID:  19026439     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
INTRODUCTION: The present case-control study was designed in order to investigate the association between plasma protein Z (PZ) levels, the intron F G79A polymorphism and unexplained pregnancy loss. MATERIALS AND METHODS: 51 women with at least two consecutive or three non-consecutive fetal losses between the 8th and 12th week of gestation and 47 apparently healthy parous women of reproductive age with no history of pregnancy loss (controls) were enrolled. Allele frequencies of the PZ intron F G79A polymorphism and PZ levels were measured. RESULTS: PZ levels (mg/L) were significantly lower in cases (mean +/- S.D. 1.28 +/- 0.56) than controls (1.97 +/- 0.76, p < 0.001) and in carriers of the A allele (1.46 +/- 0.62), compared to GG homozygous subjects (1.72 +/- 0.81, p = 0.044). A higher proportion of cases (41.2%) were PZ-deficient (<1 mg/L), compared to controls (10.6%, p = 0.001). No significant difference in the frequency of at least one A allele carriers was observed between cases (39.2%) and controls (40.4%). CONCLUSION(S): It is possible that low PZ levels are a novel risk factor for unexplained recurrent miscarriage or fetal death. The presence of the F 79A allele is associated with significantly lower PZ levels, but, in the present study, was unrelated to unexplained early pregnancy loss.
Authors:
Maria Topalidou; Smaragda Effraimidou; Dimitrios Farmakiotis; Emmanuil Papadakis; Georgia Papaioannou; Ioannis Korantzis; Vassilia Garipidou
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Publication Detail:
Type:  Journal Article     Date:  2008-11-20
Journal Detail:
Title:  Thrombosis research     Volume:  124     ISSN:  1879-2472     ISO Abbreviation:  Thromb. Res.     Publication Date:  2009 May 
Date Detail:
Created Date:  2009-04-24     Completed Date:  2009-10-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0326377     Medline TA:  Thromb Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  24-7     Citation Subset:  IM    
Affiliation:
Haemostasis Unit, Department of Haematology, Papageorgiou General Hospital, Thessaloniki, Greece.
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MeSH Terms
Descriptor/Qualifier:
Abortion, Habitual / genetics*
Adult
Alleles
Blood Proteins / genetics*
Case-Control Studies
Cohort Studies
Female
Gene Frequency
Genetic Predisposition to Disease
Genotype
Heterozygote
Homozygote
Hospitals, University
Humans
Introns / genetics
Polymorphism, Genetic*
Pregnancy
Risk Factors
Chemical
Reg. No./Substance:
0/Blood Proteins; 0/plasma protein Z

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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