| Low prolactin levels in cerebrospinal fluid: an after effect of lobotomy in chronic schizophrenia. | |
MedLine Citation:
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PMID: 7282416 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In order to elucidate the interplay of prolactin and dopamine in schizophrenia, base-line levels of prolactin were assayed in the cerebrospinal fluid (CSF) of chronic schizophrenic patients with or without lobotomy. Cental and cortical atrophy and significantly lowered CSF prolactin levels were found in lobotomized patients in comparison to equally neuroleptic-treated non-lobotomized patients. The mean CSF prolactin level in the female patients was significantly higher than in the male patients. This study did not support the 'dopamine hypothesis' of schizophrenia, since CSF prolactin levels did not correlate with schizophrenic symptoms. The brain atrophy blocked completely the expected elevation of CSF prolactin levels induced by neuroleptics. |
Authors:
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M T Hyyppä; J Liira; R Kampman; R Rimòn |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Acta psychiatrica Belgica Volume: 80 ISSN: 0300-8967 ISO Abbreviation: Acta Psychiatr Belg Publication Date: 1980 Jul-Aug |
Date Detail:
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Created Date: 1981-11-18 Completed Date: 1981-11-18 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0247037 Medline TA: Acta Psychiatr Belg Country: BELGIUM |
Other Details:
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Languages: eng Pagination: 452-7 Citation Subset: IM |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Female Frontal Lobe Humans Male Middle Aged Prolactin / cerebrospinal fluid* Psychosurgery / adverse effects* Schizophrenia / cerebrospinal fluid*, surgery Sex Factors |
| Chemical | |
Reg. No./Substance:
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9002-62-4/Prolactin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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