Document Detail

Low prolactin levels in cerebrospinal fluid: an after effect of lobotomy in chronic schizophrenia.
MedLine Citation:
PMID:  7282416     Owner:  NLM     Status:  MEDLINE    
In order to elucidate the interplay of prolactin and dopamine in schizophrenia, base-line levels of prolactin were assayed in the cerebrospinal fluid (CSF) of chronic schizophrenic patients with or without lobotomy. Cental and cortical atrophy and significantly lowered CSF prolactin levels were found in lobotomized patients in comparison to equally neuroleptic-treated non-lobotomized patients. The mean CSF prolactin level in the female patients was significantly higher than in the male patients. This study did not support the 'dopamine hypothesis' of schizophrenia, since CSF prolactin levels did not correlate with schizophrenic symptoms. The brain atrophy blocked completely the expected elevation of CSF prolactin levels induced by neuroleptics.
M T Hyyppä; J Liira; R Kampman; R Rimòn
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta psychiatrica Belgica     Volume:  80     ISSN:  0300-8967     ISO Abbreviation:  Acta Psychiatr Belg     Publication Date:    1980 Jul-Aug
Date Detail:
Created Date:  1981-11-18     Completed Date:  1981-11-18     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0247037     Medline TA:  Acta Psychiatr Belg     Country:  BELGIUM    
Other Details:
Languages:  eng     Pagination:  452-7     Citation Subset:  IM    
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MeSH Terms
Frontal Lobe
Middle Aged
Prolactin / cerebrospinal fluid*
Psychosurgery / adverse effects*
Schizophrenia / cerebrospinal fluid*,  surgery
Sex Factors
Reg. No./Substance:

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